Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | CFTR | P13569 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7035878 | 0.81 | ALDH1A1 (0.52) | SMN1; SMN2ALDH1A1POLBNPSR1PTGER4 | |
| SCHEMBL6073339 | 0.79 | CFTR (0.44) | SMN1; SMN2ALDH1A1POLBGAANPSR1 | |
| SCHEMBL11156490 | 0.78 | POLB (0.37) | ALDH1A1POLBCNR2HTTHDAC1 | |
| SCHEMBL140210 | 0.77 | TSHR (0.36) | SMN1; SMN2ALDH1A1POLBCNR2TSHR | |
| SCHEMBL30853648 | 0.77 | TSHR (0.36) | SMN1; SMN2ALDH1A1POLBCNR2TSHR | |
| SCHEMBL11152774 | 0.77 | CYP3A4 (0.42) | ALDH1A1CNR2TSHRNPSR1ABCB11 | |
| SCHEMBL7034248 | 0.76 | ALDH1A1 (0.46) | SMN1; SMN2ALDH1A1POLBGAANPSR1 | |
| SCHEMBL11266735 | 0.75 | AR (0.42) | SMN1; SMN2ALDH1A1HTTTSHRNPSR1 | |
| SCHEMBL665559 | 0.73 | CYP1A2 (0.53) | SMN1; SMN2ALDH1A1CNR2HTTMMP8 | |
| SCHEMBL9076682 | 0.72 | ALDH1A1 (0.46) | SMN1; SMN2ALDH1A1HTTTSHRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0922704-B1 | PROCESS FOR PREPARING 2-(10,11-DIHYDRO-10-OXODIBENZO b,f]THIEPIN-2-YL)PROPIONIC ACID AND INTERMEDIATES THEREFOR | NIPPON CHEMIPHAR CO (JP) | 2003-03-05 | — | — | EP | disclosed |
| US-6111115-A | Preparation of 2-(10,11-dihydro-10-oxodibenzo-[b,f]thiepin-2-yl) propionic acid | NIPPON CHEMIPHAR CO., LTD. (JP) | 2000-08-29 | — | — | US | disclosed |
| EP-0922704-A1 | PROCESS FOR PREPARING 2-(10,11-DIHYDRO-10-OXODIBENZO b,f]THIEPIN-2-YL)PROPIONIC ACID AND INTERMEDIATES THEREFOR | NIPPON CHEMIPHAR CO., LTD. (JP) | 1999-06-16 | — | — | EP | disclosed |