Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | GALR2 | O43603 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | CCR6 | P51684 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | USP10 | Q14694 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7035878 | 0.94 | ALDH1A1 (0.52) | ALDH1A1MAPTSMN1; SMN2LMNAMAPK1 | |
| SCHEMBL27406843 | 0.88 | ALDH1A1 (0.43) | ALDH1A1MAPTSMN1; SMN2LMNAMAPK1 | |
| SCHEMBL7036922 | 0.83 | ALDH1A1 (0.50) | ALDH1A1MAPTSMN1; SMN2LMNAMAPK1 | |
| SCHEMBL7028236 | 0.80 | MAPT (0.39) | ALDH1A1MAPTSMN1; SMN2LMNAMAPK1 | |
| SCHEMBL19255154 | 0.78 | MAPT (0.48) | ALDH1A1MAPTSMN1; SMN2LMNAMAPK1 | |
| SCHEMBL11152796 | 0.77 | NPSR1 (0.46) | ALDH1A1MAPTSMN1; SMN2LMNATDP1 | |
| SCHEMBL142930 | 0.77 | THRB (0.44) | ALDH1A1MAPTSMN1; SMN2LMNATDP1 | |
| SCHEMBL7035586 | 0.77 | THRB (0.52) | ALDH1A1MAPTLMNAMAPK1KMT2A | |
| SCHEMBL6072903 | 0.76 | HPD (0.47) | ALDH1A1MAPTLMNAMAPK1KMT2A | |
| SCHEMBL7036366 | 0.76 | SMN1; SMN2 (0.36) | ALDH1A1SMN1; SMN2NPSR1POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0922704-B1 | PROCESS FOR PREPARING 2-(10,11-DIHYDRO-10-OXODIBENZO b,f]THIEPIN-2-YL)PROPIONIC ACID AND INTERMEDIATES THEREFOR | NIPPON CHEMIPHAR CO (JP) | 2003-03-05 | — | — | EP | disclosed |
| US-6111115-A | Preparation of 2-(10,11-dihydro-10-oxodibenzo-[b,f]thiepin-2-yl) propionic acid | NIPPON CHEMIPHAR CO., LTD. (JP) | 2000-08-29 | — | — | US | disclosed |
| EP-0922704-A1 | PROCESS FOR PREPARING 2-(10,11-DIHYDRO-10-OXODIBENZO b,f]THIEPIN-2-YL)PROPIONIC ACID AND INTERMEDIATES THEREFOR | NIPPON CHEMIPHAR CO., LTD. (JP) | 1999-06-16 | — | — | EP | disclosed |