Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 14/20 | 0.43 |
| ▸ | POLQ | O75417 | 3/20 | 0.41 |
| ▸ | XIAP | P98170 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7854689 | 0.89 | KCNH2 (0.47) | KCNH2SCN9APOLQP2RX7 | |
| SCHEMBL7036494 | 0.89 | KCNH2 (0.57) | KCNH2SCN9APOLQXIAP | |
| SCHEMBL7041178 | 0.86 | SIGMAR1 (0.44) | SCN9AP2RX7 | |
| SCHEMBL8613701 | 0.86 | KCNH2 (0.48) | KCNH2POLQP2RX7 | |
| SCHEMBL7037039 | 0.79 | P2RX7 (0.48) | KCNH2XIAPP2RX7 | |
| SCHEMBL8760273 | 0.76 | KCNH2 (0.75) | KCNH2 | |
| SCHEMBL7036499 | 0.76 | KCNH2 (0.49) | KCNH2SCN9APOLQXIAPP2RX7 | |
| SCHEMBL7854692 | 0.74 | KCNH2 (0.49) | KCNH2SCN9APOLQXIAPP2RX7 | |
| SCHEMBL7036496 | 0.74 | KCNH2 (0.57) | KCNH2SCN9APOLQXIAP | |
| SCHEMBL7744698 | 0.72 | KCNH2 (0.47) | KCNH2SCN9APOLQXIAPP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0833819-B1 | NOVEL N-(2-OXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3YL)-3-AMIDES | MERCK & CO INC (US) | 2003-03-26 | — | — | EP | claimed |
| EP-0833819-A4 | NOVEL N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3YL)-3-AMIDES | MERCK & CO INC (US) | 1998-11-11 | — | — | EP | claimed |
| EP-0833819-A1 | NOVEL N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3YL)-3-AMIDES | Merck & Co., Inc. (US) | 1998-04-08 | — | — | EP | claimed |
| US-5691332-A | N-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-amides | MERCK & CO., INC. (US) | 1997-11-25 | — | — | US | claimed |
| WO-1996040656-A1 | NOVEL N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3YL)-3-AMIDES | MERCK & CO., INC. (US) | 1996-12-19 | — | — | WO | claimed |
| EP-0833819-B1 | NOVEL N-(2-OXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3YL)-3-AMIDES | MERCK & CO INC (US) | 2003-03-26 | — | — | EP | disclosed |
| EP-0833819-A4 | NOVEL N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3YL)-3-AMIDES | MERCK & CO INC (US) | 1998-11-11 | — | — | EP | disclosed |
| EP-0833819-A1 | NOVEL N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3YL)-3-AMIDES | Merck & Co., Inc. (US) | 1998-04-08 | — | — | EP | disclosed |
| US-5691332-A | N-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-amides | MERCK & CO., INC. (US) | 1997-11-25 | — | — | US | disclosed |
| WO-1996040656-A1 | NOVEL N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3YL)-3-AMIDES | MERCK & CO., INC. (US) | 1996-12-19 | — | — | WO | disclosed |