Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.41 |
| ▸ | MEN1 | O00255 | 7/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | HCK | P08631 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.37 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL700426 | 0.81 | RECQL (0.40) | ALDH1A1TDP1KMT2AMEN1CNR1 | |
| SCHEMBL701757 | 0.79 | ALDH1A1 (0.50) | ALDH1A1TDP1KMT2AMEN1POLB | |
| SCHEMBL15504707 | 0.73 | ALDH1A1 (0.61) | ALDH1A1TDP1KMT2AMEN1POLB | |
| SCHEMBL15504651 | 0.73 | ALDH1A1 (0.61) | ALDH1A1TDP1KMT2AMEN1POLB | |
| SCHEMBL701598 | 0.71 | ALDH1A1 (0.50) | ALDH1A1TDP1KMT2AMEN1POLB | |
| SCHEMBL7978681 | 0.70 | MEN1 (0.48) | ALDH1A1TDP1KMT2AMEN1POLB | |
| SCHEMBL1247579 | 0.70 | MIF (0.50) | ALDH1A1 | |
| SCHEMBL28402688 | 0.68 | MEN1 (0.48) | ALDH1A1TDP1KMT2AMEN1POLB | |
| SCHEMBL15617660 | 0.67 | CYP2C19 (0.51) | ALDH1A1TDP1KMT2AMEN1CNR1 | |
| SCHEMBL15617595 | 0.66 | CNR1 (0.56) | ALDH1A1TDP1KMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124621-B2 | Substituted 1-amino-4-phenyl-dihydroisoquinolines, methods for the production thereof, use thereof as a medicament, and medicaments containing them | SANOFI-AVENTIS (FR) | 2012-02-28 | — | — | US | disclosed |
| EP-1999113-B1 | SUBSTITUTED 1-AMINO-4-PHENYL-DIHYDROISOQUINOLINES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT, AND MEDICAMENTS CONTAINING THEM | SANOFI AVENTIS (FR) | 2009-08-19 | — | — | EP | disclosed |
| US-20090118327-A1 | SUBSTITUTED 1-AMINO-4-PHENYL-DIHYDROISOQUINOLINES, METHODS FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT, AND MEDICAMENTS CONTAINING THEM | SANOFI-AVENTIS (FR) | 2009-05-07 | — | — | US | disclosed |
| CN-101405269-A | Substituted 1-amino-4-phenyldihydroisoquinolines, method for the production thereof, use thereof as medicaments and medicaments containing the same | SANOFI AVENTIS (FR) | 2009-04-08 | — | — | CN | disclosed |
| EP-1999113-A1 | SUBSTITUTED 1-AMINO-4-PHENYL-DIHYDROISOQUINOLINES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT, AND MEDICAMENTS CONTAINING THEM | Sanofi-Aventis (FR) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007107245-A1 | SUBSTITUTED 1-AMINO-4-PHENYL-DIHYDROISOQUINOLINES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT, AND MEDICAMENTS CONTAINING THEM | SANOFI-AVENTIS (FR) | 2007-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118327-A1 | SUBSTITUTED 1-AMINO-4-PHENYL-DIHYDROISOQUINOLINES, METHODS FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT, AND MEDICAMENTS CONTAINING THEM | NDUFAB1, ABCB11, SLC10A1 | ALDH1A1 181/4885TDP1 2355/4885KMT2A 2047/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.