Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 8/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | NQO2 | P16083 | 1/20 | 0.46 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.45 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7037076 | 0.91 | CHEK2 (0.65) | CHEK2HDAC6MAPTTP53POLB | |
| SCHEMBL7033087 | 0.90 | SMN1; SMN2 (0.53) | CHEK2HDAC6MAPTTP53POLB | |
| SCHEMBL1664788 | 0.87 | CHEK2 (0.68) | CHEK2MAPTTP53POLBKDM4E | |
| SCHEMBL7036871 | 0.85 | KDM4E (0.48) | CHEK2HDAC6MAPTPOLBTDP1 | |
| SCHEMBL7039869 | 0.83 | CHEK2 (0.53) | CHEK2HDAC6MAPTPOLBTDP1 | |
| SCHEMBL1662758 | 0.80 | CHEK2 (0.76) | CHEK2MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL7035502 | 0.80 | KDM4E (0.71) | CHEK2HDAC6MAPTTP53POLB | |
| SCHEMBL3916748 | 0.79 | CHEK2 (0.82) | CHEK2MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL7034855 | 0.79 | CHEK2 (0.54) | CHEK2MAPTPOLBKDM4EALDH1A1 | |
| SCHEMBL7041702 | 0.78 | MMP2 (0.54) | CHEK2HDAC6TDP1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030104473-A1 | Common ligand mimics: benzimidazoles | TRIAD THERAPEUTICS, INC. | 2003-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030104473-A1 | Common ligand mimics: benzimidazoles | BID, LIFR, FGFR3 | CHEK2 2711/4885HDAC6 841/4885MAPT 4471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.