Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD51 | Q06609 | 7/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31215212 | 0.74 | HIF1A (0.55) | RAD51ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL18031313 | 0.72 | RAD51 (0.41) | RAD51ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL31612337 | 0.72 | RAD51 (0.72) | RAD51ALDH1A1KDM4EMAPTMAPK14 | |
| SCHEMBL14143168 | 0.71 | ALDH1A1 (0.58) | RAD51ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL4326394 | 0.71 | RORC (0.57) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL6362818 | 0.70 | MAPT (0.46) | RAD51ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL18031314 | 0.69 | MAP2K3 (0.54) | RAD51ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL31214662 | 0.69 | KDM4E (0.53) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL31215208 | 0.69 | HIF1A (0.64) | RAD51ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL6039844 | 0.68 | KDM4E (0.46) | RAD51ALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004058755-A2 | COMPOUND LIBRARIES OF IMIDAZO[1,5-A]PYRIDIN-3-YL DERIVATIVES AND RELATED HETEROBICYCLES FOR TARGETTING COMPOUNDS CAPABLE OF BINDING TO G-PROTEIN COUPLED RECEPTORS | BIOFOCUS PLC (GB) | 2004-07-15 | — | — | WO | disclosed |