Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6412219 | 0.82 | POLB (0.50) | POLBRIPK1MEN1KMT2AGAA | |
| SCHEMBL7957710 | 0.78 | TYMP (0.42) | MEN1KMT2AMAPTLMNA | |
| SCHEMBL8185024 | 0.78 | TSHR (0.49) | POLBRIPK1MEN1KMT2AGAA | |
| SCHEMBL4439049 | 0.78 | HPGDS (0.50) | KMT2AGAA | |
| SCHEMBL10589328 | 0.76 | SCN2A (0.48) | MEN1KMT2AGAAMAPTRAB9A | |
| SCHEMBL10587244 | 0.75 | POLB (0.43) | POLBRIPK1GRIN1GRIN2BMAPT | |
| SCHEMBL6688212 | 0.75 | TYMP (0.45) | LOXL2GRIN1GRIN2BMAPTRAB9A | |
| SCHEMBL177700 | 0.71 | TAAR1 (0.57) | POLBRIPK1MEN1KMT2AGAA | |
| SCHEMBL18021893 | 0.71 | POLB (0.51) | POLBRIPK1MEN1KMT2AGAA | |
| SCHEMBL44366 | 0.71 | POLB (0.76) | POLBMEN1KMT2ALOXL2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003006012-A1 | COMPOUNDS AND METHODS FOR THE INHIBITION OF TRYPANOSOMA CRUZ I | YALE UNIVERSITY (US) | 2003-01-23 | — | — | WO | disclosed |