Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8185024 | 0.85 | TSHR (0.49) | POLBTSHRMAPTALDH1A1CYP2C19 | |
| SCHEMBL7345076 | 0.82 | BRS3 (0.49) | — | |
| SCHEMBL6412219 | 0.77 | POLB (0.50) | POLBTSHRMAPTALDH1A1RIPK1 | |
| SCHEMBL7842828 | 0.77 | BRS3 (0.54) | PTGDR2GRIN1GRIN2B | |
| SCHEMBL7039342 | 0.75 | POLB (0.47) | POLBTSHRMAPTALDH1A1RIPK1 | |
| SCHEMBL17154340 | 0.75 | CYP2C19 (0.58) | POLBTSHRMAPTALDH1A1CYP2C19 | |
| SCHEMBL28021741 | 0.74 | LTA4H (0.43) | POLBTSHRMAPTALDH1A1CYP2C19 | |
| SCHEMBL30643815 | 0.73 | CYP2C19 (0.64) | TSHRMAPTALDH1A1CYP2C19CYP1A2 | |
| SCHEMBL76204 | 0.73 | CYP2C19 (0.64) | TSHRMAPTALDH1A1CYP2C19CYP1A2 | |
| Hydrochloric Acid SCHEMBL8388746 | 0.73 | CYP1A2 (0.46) | CYP1A2PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0324377-A2 | Angiotensin II receptor blocking imidazoles and combinations thereof with diuretics and NSaids | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-07-19 | — | — | EP | disclosed |