Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7039902 | 0.83 | GAA (0.35) | SMN1; SMN2LMNAPOLBRAB9A | |
| Hydrochloric Acid SCHEMBL7174111 | 0.80 | — | — | |
| Hydrochloric Acid SCHEMBL7041823 | 0.72 | SMN1; SMN2 (0.32) | SMN1; SMN2LMNARAB9A | |
| Hydrochloric Acid SCHEMBL7243552 | 0.71 | SMN1; SMN2 (0.33) | ADORA3SMN1; SMN2LMNAPOLBRAB9A | |
| Hydrochloric Acid SCHEMBL7247941 | 0.66 | RAB9A (0.32) | ADORA3SMN1; SMN2LMNAPOLBRAB9A | |
| SCHEMBL8022750 | 0.64 | — | — | |
| Hydrochloric Acid SCHEMBL7040765 | 0.63 | SMN1; SMN2 (0.33) | SMN1; SMN2LMNARAB9A | |
| Hydrochloric Acid SCHEMBL7041468 | 0.63 | SMN1; SMN2 (0.33) | SMN1; SMN2LMNARAB9A | |
| Hydrochloric Acid SCHEMBL3821780 | 0.62 | NPC1 (0.36) | SMN1; SMN2LMNAPOLBRAB9A | |
| SCHEMBL17192654 | 0.53 | HDAC3 (0.48) | SMN1; SMN2LMNAPOLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1017701-B1 | CYCLOPENTAPHENANTHRENYL TITANIUM COMPLEXES AND POLYMERIZATION PROCESS | DOW GLOBAL TECHNOLOGIES INC (US) | 2003-03-19 | — | — | EP | claimed |
| US-6323294-B1 | CONTACTING C.SUB.2-100,000 OLEFIN/S UNDER POLYMERIZATION CONDITIONS WITH CATALYST SYSTEM COMPRISING METAL COMPLEX AND ACTIVATING COCATALYST OR REACTION PRODUCT OF METAL COMPLEX AND COCATALYST TO FORM ADDITION POLYMER | THE DOW CHEMICAL COMPANY | 2001-11-27 | — | — | US | claimed |
| EP-1017701-B1 | CYCLOPENTAPHENANTHRENYL TITANIUM COMPLEXES AND POLYMERIZATION PROCESS | DOW GLOBAL TECHNOLOGIES INC (US) | 2003-03-19 | — | — | EP | disclosed |
| US-6323294-B1 | CONTACTING C.SUB.2-100,000 OLEFIN/S UNDER POLYMERIZATION CONDITIONS WITH CATALYST SYSTEM COMPRISING METAL COMPLEX AND ACTIVATING COCATALYST OR REACTION PRODUCT OF METAL COMPLEX AND COCATALYST TO FORM ADDITION POLYMER | THE DOW CHEMICAL COMPANY | 2001-11-27 | — | — | US | disclosed |
| US-6150297-A | Cyclopentaphenanthrenyl metal complexes and polymerization process | THE DOW CHEMICAL COMPANY (US) | 2000-11-21 | — | — | US | disclosed |