Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TERT | O14746 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7041774 | 0.98 | SMN1; SMN2 (0.37) | SMN1; SMN2THRBCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7041918 | 0.89 | PARP1 (0.40) | SMN1; SMN2THRBTERTPARP1TP53 | |
| SCHEMBL7708432 | 0.87 | PARP1 (0.45) | THRBTERTPARP1 | |
| SCHEMBL7046250 | 0.87 | PARP1 (0.38) | SMN1; SMN2THRBTERTPARP1NPC1 | |
| SCHEMBL7041579 | 0.87 | JAK2 (0.40) | SMN1; SMN2THRBCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7706399 | 0.85 | PARP1 (0.43) | THRBPARP1NPC1 | |
| SCHEMBL7041533 | 0.84 | HTR3A (0.40) | HTR3A | |
| SCHEMBL7043890 | 0.84 | PARP1 (0.35) | SMN1; SMN2THRBCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7041448 | 0.83 | TAAR1 (0.36) | SMN1; SMN2THRBCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7046613 | 0.83 | HTR3A (0.40) | HTR3APARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133477-B1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | ABBOTT GMBH & CO KG (DE) | 2004-02-18 | — | — | EP | disclosed |
| EP-1133477-A1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-09-19 | — | — | EP | disclosed |
| WO-2000032579-A1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2000-06-08 | — | — | WO | disclosed |