Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.48 |
| ▸ | JAK1 | P23458 | 8/20 | 0.48 |
| ▸ | TYK2 | P29597 | 8/20 | 0.48 |
| ▸ | JAK3 | P52333 | 8/20 | 0.48 |
| ▸ | PARP1 | P09874 | 5/20 | 0.39 |
| ▸ | HRH1 | P35367 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7041387 | 0.94 | JAK2 (0.42) | JAK2JAK1TYK2JAK3PARP1 | |
| SCHEMBL7046803 | 0.92 | JAK2 (0.58) | JAK2JAK1TYK2JAK3PARP1 | |
| SCHEMBL7045084 | 0.89 | JAK2 (0.46) | JAK2JAK1TYK2JAK3PARP1 | |
| SCHEMBL7041855 | 0.88 | JAK2 (0.46) | JAK2JAK1TYK2JAK3PARP1 | |
| SCHEMBL7041213 | 0.88 | CHRM1 (0.46) | JAK2JAK1TYK2JAK3PARP1 | |
| SCHEMBL7046373 | 0.88 | JAK2 (0.45) | JAK2JAK1TYK2JAK3PARP1 | |
| SCHEMBL7040421 | 0.87 | JAK2 (0.44) | JAK2JAK1TYK2JAK3PARP1 | |
| SCHEMBL7044226 | 0.86 | JAK2 (0.51) | JAK2JAK1TYK2JAK3PARP1 | |
| SCHEMBL7043682 | 0.85 | PARP1 (0.57) | JAK2JAK1TYK2JAK3PARP1 | |
| SCHEMBL7042003 | 0.85 | PARP1 (0.48) | JAK2JAK1TYK2JAK3PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133477-B1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | ABBOTT GMBH & CO KG (DE) | 2004-02-18 | — | — | EP | disclosed |
| EP-1133477-A1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-09-19 | — | — | EP | disclosed |
| WO-2000032579-A1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2000-06-08 | — | — | WO | disclosed |