Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 7/20 | 0.48 |
| ▸ | JAK2 | O60674 | 3/20 | 0.41 |
| ▸ | JAK1 | P23458 | 3/20 | 0.41 |
| ▸ | TYK2 | P29597 | 3/20 | 0.41 |
| ▸ | JAK3 | P52333 | 3/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | JUND | P17535 | 1/20 | 0.34 |
| ▸ | FOSB | P53539 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7043077 | 0.93 | PARP1 (0.44) | PARP1JAK2JAK1TYK2JAK3 | |
| SCHEMBL7040201 | 0.87 | PARP1 (0.54) | PARP1PARP2HTR2BMEN1KMT2A | |
| SCHEMBL7041855 | 0.86 | JAK2 (0.46) | PARP1JAK2JAK1TYK2JAK3 | |
| SCHEMBL7038555 | 0.86 | PIM1 (0.45) | PARP1JAK2JAK1TYK2JAK3 | |
| SCHEMBL7046803 | 0.85 | JAK2 (0.58) | PARP1JAK2JAK1TYK2JAK3 | |
| SCHEMBL7040992 | 0.85 | JAK2 (0.48) | PARP1JAK2JAK1TYK2JAK3 | |
| SCHEMBL7045084 | 0.84 | JAK2 (0.46) | PARP1JAK2JAK1TYK2JAK3 | |
| SCHEMBL7046373 | 0.84 | JAK2 (0.45) | PARP1JAK2JAK1TYK2JAK3 | |
| SCHEMBL7045615 | 0.84 | PARP1 (0.51) | PARP1PARP2HTR2B | |
| SCHEMBL7040671 | 0.83 | PARP1 (0.50) | PARP1PARP2HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133477-B1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | ABBOTT GMBH & CO KG (DE) | 2004-02-18 | — | — | EP | disclosed |