Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.42 |
| ▸ | JAK1 | P23458 | 6/20 | 0.42 |
| ▸ | TYK2 | P29597 | 6/20 | 0.42 |
| ▸ | JAK3 | P52333 | 6/20 | 0.42 |
| ▸ | HRH1 | P35367 | 3/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 5/20 | 0.39 |
| ▸ | NPY1R | P25929 | 6/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7041213 | 0.94 | CHRM1 (0.46) | JAK2JAK1TYK2JAK3HRH1 | |
| SCHEMBL7040992 | 0.94 | JAK2 (0.48) | JAK2JAK1TYK2JAK3HRH1 | |
| SCHEMBL7044226 | 0.92 | JAK2 (0.51) | JAK2JAK1TYK2JAK3HRH1 | |
| SCHEMBL7044268 | 0.89 | HRH1 (0.41) | JAK2JAK1TYK2JAK3HRH1 | |
| SCHEMBL7043328 | 0.89 | JAK2 (0.40) | JAK2JAK1TYK2JAK3HRH1 | |
| SCHEMBL7044872 | 0.89 | JAK2 (0.39) | JAK2JAK1TYK2JAK3HRH1 | |
| SCHEMBL7042457 | 0.89 | JAK2 (0.39) | JAK2JAK1TYK2JAK3HRH1 | |
| SCHEMBL7042033 | 0.88 | NPY1R (0.40) | JAK2JAK1TYK2JAK3HRH1 | |
| SCHEMBL7043993 | 0.86 | CHRM1 (0.46) | JAK2JAK1TYK2JAK3HRH1 | |
| SCHEMBL7046803 | 0.86 | JAK2 (0.58) | JAK2JAK1TYK2JAK3PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133477-B1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | ABBOTT GMBH & CO KG (DE) | 2004-02-18 | — | — | EP | disclosed |
| EP-1133477-A1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-09-19 | — | — | EP | disclosed |
| WO-2000032579-A1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2000-06-08 | — | — | WO | disclosed |