Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.63 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 2/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11791404 | 0.89 | ALDH1A1 (0.61) | POLBPTGS2ALDH1A1TDP1KDM4E | |
| SCHEMBL3912992 | 0.86 | POLB (0.62) | POLBPTGS2ALDH1A1TDP1KDM4E | |
| SCHEMBL14266881 | 0.82 | GFER (0.58) | ALDH1A1TDP1KDM4EGAALMNA | |
| SCHEMBL79445 | 0.82 | HDAC2 (0.64) | POLBPTGS2ALDH1A1TDP1KDM4E | |
| SCHEMBL31456325 | 0.81 | POLB (0.67) | POLBPTGS2ALDH1A1TDP1KDM4E | |
| SCHEMBL19663861 | 0.80 | ALDH1A1 (0.78) | POLBPTGS2ALDH1A1TDP1KDM4E | |
| SCHEMBL16380418 | 0.80 | PTGS2 (0.64) | POLBPTGS2ALDH1A1TDP1KDM4E | |
| SCHEMBL28680084 | 0.79 | ALDH1A1 (0.55) | POLBPTGS2ALDH1A1TDP1KDM4E | |
| SCHEMBL24386087 | 0.79 | MAPT (0.47) | POLBPTGS2ALDH1A1TDP1KDM4E | |
| SCHEMBL11536811 | 0.78 | HDAC1 (0.51) | POLBPTGS2ALDH1A1TDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0982292-B1 | Process for the preparation of monoacylhydrazines using carboxylic acids | DOW AGROSCIENCES LLC (US) | 2003-03-26 | — | — | EP | disclosed |
| US-6096890-A | Process for substituted hydrazides using carboxylic acids | ROHM AND HAAS COMPANY (US) | 2000-08-01 | — | — | US | disclosed |
| EP-0982292-A2 | Process for the preparation of monoacylhydrazines using carboxylic acids | ROHM AND HAAS COMPANY (US) | 2000-03-01 | — | — | EP | disclosed |
| US-5767314-A | Selective acylation of monoalkylhydrazines | ROHM AND HAAS COMPANY (US) | 1998-06-16 | — | — | US | disclosed |
| US-5675037-A | REACTING UNSUBSTITUTED OR MONOALKYL-HYDRAZINES WITH TRICHLOROMETHYL ARYL KETONES | ROHM AND HAAS COMPANY (US) | 1997-10-07 | — | — | US | disclosed |
| EP-0492839-B1 | Selective acylation of hydrazines | ROHM & HAAS (US) | 1995-04-12 | — | — | EP | disclosed |
| EP-0492839-A1 | Selective acylation of hydrazines | ROHM AND HAAS COMPANY (US) | 1992-07-01 | — | — | EP | disclosed |
| US-4309422-A | INSECTICIDES | VELSICOL CHEMICAL CORPORATION (US) | 1982-01-05 | — | — | US | disclosed |
| US-4198513-A | ANTI-GOUT AND ANTI-HYPERURICEMIC AGENTS | MERCK & CO., INC. (US) | 1980-04-15 | — | — | US | disclosed |
| US-4156085-A | ANTIGOUT, XANTHINE OXIDASE INHIBITORS | MERCK & CO., INC. (US) | 1979-05-22 | — | — | US | disclosed |
| US-4111944-A | SUBSTITUTED 1,2,4-TRIAZOLES | MERCK & CO., INC. (US) | 1978-09-05 | — | — | US | disclosed |
| US-4102889-A | ANTIGOUT AND ANTIHYPERURICEMIC AGENTS | MERCK & CO., INC. (US) | 1978-07-25 | — | — | US | disclosed |
| US-4011218-A | ANTI-GOUT, ANTI-HYPERURICEMIC | MERCK & CO., INC. (US) | 1977-03-08 | — | — | US | disclosed |
| US-3963731-A | TREATMENT OF GOUT AND HYPERURICEMIA | MERCK & CO., INC. (US) | 1976-06-15 | — | — | US | disclosed |
| US-3947577-A | 1,2,4-TRIAZOLES | MERCK & CO., INC. (US) | 1976-03-30 | — | — | US | disclosed |