Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.30 |
| ▸ | THRA | P10827 | 1/20 | 0.30 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5208590 | 0.75 | ALDH1A1 (0.42) | ALDH1A1HPGDHTTMEN1KMT2A | |
| SCHEMBL6136980 | 0.69 | CXCL8 (0.36) | ALDH1A1MAPT | |
| SCHEMBL23021682 | 0.68 | ALDH1A1 (0.51) | ALDH1A1HPGDHTTMEN1KMT2A | |
| SCHEMBL3791684 | 0.67 | SMN1; SMN2 (0.52) | ALDH1A1HPGDHTTMEN1KMT2A | |
| SCHEMBL19286776 | 0.65 | CTBP2 (0.50) | ALDH1A1HTTKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL23021795 | 0.61 | ALDH1A1 (0.47) | ALDH1A1HPGDHTTMEN1KMT2A | |
| SCHEMBL15434614 | 0.60 | GABRA1 (0.41) | ALDH1A1HTTMEN1KMT2AMAPT | |
| SCHEMBL3780795 | 0.60 | HPGD (0.58) | ALDH1A1HPGDHTTMEN1KMT2A | |
| SCHEMBL27308477 | 0.60 | CLCN2 (0.54) | ALDH1A1HPGDMEN1KMT2AMAPT | |
| SCHEMBL18931210 | 0.60 | ALDH1A1 (0.50) | ALDH1A1HPGDHTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882029-B1 | HETEROCYCLIC DERIVATIVES AS ANTIDIABETIC AND ANTIOBESITY AGENTS | MERCK & CO INC (US) | 2003-04-02 | — | — | EP | disclosed |
| US-6090836-A | DIETETICS; ADJUSTMENT OF TRIGLYCERIDE CONCENTRATION | MERCK & CO., INC. (US) | 2000-07-18 | — | — | US | disclosed |
| EP-0882029-A1 | HETEROCYCLIC DERIVATIVES AS ANTIDIABETIC AND ANTIOBESITY AGENTS | Merck & Co., Inc. (US) | 1998-12-09 | — | — | EP | disclosed |
| WO-1997028137-A1 | HETEROCYCLIC DERIVATIVES AS ANTIDIABETIC AND ANTIOBESITY AGENTS | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | disclosed |