Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 4/20 | 1.00 |
| ▸ | MPO | P05164 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | ABCG2 | Q9UNQ0 | 6/20 | 0.55 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.53 |
| ▸ | IDH2 | P48735 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | ARNT | P27540 | 1/20 | 0.50 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16208490 | 0.89 | KIF11 (0.81) | KIF11MPOMEN1LMNAMAPT | |
| SCHEMBL6841678 | 0.88 | KIF11 (0.78) | KIF11MPOMEN1LMNAMAPT | |
| SCHEMBL12266442 | 0.85 | KIF11 (0.74) | KIF11MPOMEN1LMNAMAPT | |
| SCHEMBL16230308 | 0.84 | KIF11 (0.71) | KIF11MEN1LMNAMAPTKMT2A | |
| SCHEMBL27542233 | 0.84 | KIF11 (0.72) | KIF11MPOMEN1LMNAMAPT | |
| SCHEMBL20049529 | 0.84 | HPGD (0.78) | KIF11MEN1LMNAMAPTKMT2A | |
| SCHEMBL1921482 | 0.83 | KIF11 (0.70) | KIF11MAPTIDH2 | |
| SCHEMBL17103677 | 0.83 | TRPV1 (0.72) | KIF11MPOMEN1LMNAMAPT | |
| SCHEMBL29572518 | 0.83 | TRPV1 (0.72) | KIF11MPOMEN1LMNAMAPT | |
| SCHEMBL5459758 | 0.82 | KIF11 (0.69) | KIF11MEN1LMNAMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432710-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | Bayer Pharmaceuticals Corporation (US) | 2004-06-30 | — | — | EP | disclosed |
| US-6677352-B1 | 1,6-naphthyridine derivatives and their use to treat diabetes and related disorders | BAYER PHARMACEUTICALS CORPORATION | 2004-01-13 | — | — | US | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |