SCHEMBL7043288

SCHEMBL7043288

CC(=O)c1cccc(CN2CCN(c3ccccc3)CC2)c1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD4 P21917 2/20 0.60
DRD2 P14416 2/20 0.57
DRD3 P35462 1/20 0.57
ALDH1A1 P00352 1/20 0.57
L3MBTL1 Q9Y468 1/20 0.57
CYP2D6 P10635 1/20 0.55
CYP2C9 P11712 1/20 0.55
HIF1A Q16665 1/20 0.55
HTR2A P28223 1/20 0.54
HTR2C P28335 1/20 0.54
HTR2B P41595 1/20 0.54
HTR7 P34969 1/20 0.54
ITGB3 P05106 1/20 0.54
ITGA2B P08514 1/20 0.54
MAPT P10636 2/20 0.54
KDM4E B2RXH2 1/20 0.54
TP53 P04637 1/20 0.54
TSHR P16473 1/20 0.54
HSD17B10 Q99714 1/20 0.54
LMNA P02545 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2323421 0.92 DRD2 (0.64) DRD4DRD2DRD3ALDH1A1L3MBTL1
SCHEMBL31593043 0.89 CYP2D6 (0.69) DRD4DRD2DRD3ALDH1A1L3MBTL1
SCHEMBL27040086 0.89 CYP2D6 (0.69) DRD4DRD2DRD3ALDH1A1L3MBTL1
SCHEMBL6699169 0.88 ITGB3 (0.54) DRD4ALDH1A1L3MBTL1CYP2D6CYP2C9
SCHEMBL6699163 0.87 ITGB3 (0.58) ALDH1A1L3MBTL1HTR2AHTR2CHTR2B
SCHEMBL27040179 0.86 HTR7 (0.62) DRD4ALDH1A1L3MBTL1HTR7MAPT
SCHEMBL2327169 0.85 DRD4 (0.66) DRD4ALDH1A1HTR2AHTR2CHTR2B
SCHEMBL1482123 0.85 HTR2A (0.69) DRD4ALDH1A1L3MBTL1HTR2AHTR2C
SCHEMBL7043039 0.84 KDM4E (0.67) ALDH1A1CYP2D6CYP2C9HTR7MAPT
SCHEMBL7038584 0.83 SMN1; SMN2 (0.59) ALDH1A1L3MBTL1CYP2D6CYP2C9HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5817489-A BACTERICIDES, OR CHEMICAL INTERMEDIATES THEREOF; DRUG LIBRARIES ISIS PHARMACEUTICALS, INC. (US) 1998-10-06 US claimed
US-6800444-B1 USEFUL AS ANTIBACTERIAL AND OTHER PHARMACEUTICAL AGENTS/INTERMEDIATES ISIS PHARMACEUTICALS, INC. 2004-10-05 US disclosed
US-6660466-B1 Reacting reactive appendage compounds such as meta benzylic compounds or alpha-amide compounds with scaffold molecules having reactive functionalities and contacting the intermediate library with a reducing agent ISIS PHARMACEUTICALS, INC. 2003-12-09 US disclosed
US-6150129-A USEFUL AS ANTIBACTERIAL AND OTHER PHARMACEUTICAL AGENTS AND AS INTERMEDIATES FOR PREPARATION OF OTHER PHARMACEUTICAL AGENTS ISIS PHARMACEUTICALS, INC. (US) 2000-11-21 US disclosed
US-5922872-A BACTERICIDES AND DRUGS ISIS PHARMACEUTICALS, INC. (US) 1999-07-13 US disclosed
US-5817489-A BACTERICIDES, OR CHEMICAL INTERMEDIATES THEREOF; DRUG LIBRARIES ISIS PHARMACEUTICALS, INC. (US) 1998-10-06 US disclosed
US-5798360-A ANTIBACTERIAL AGENTS ISIS PHARMACEUTICALS, INC. (US) 1998-08-25 US disclosed
US-5780241-A ALTERING ELECTROCHEMICAL PROPERTIES BY DECYCLIZATION ISIS PHARMACEUTICALS, INC. (US) 1998-07-14 US disclosed
WO-1998020349-A1 COMPLEX CHEMICAL LIBRARIES ISIS PHARMACEUTICALS, INC. (US) 1998-05-14 WO disclosed
US-5731438-A BACTERICIDES; DRUGS ISIS PHARMACEUTICALS, INC. (US) 1998-03-24 US disclosed
WO-1998005332-A1 NOVEL HETEROCYCLE COMPOSITIONS ISIS PHARMACEUTICALS, INC. (US) 1998-02-12 WO disclosed