Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7043195 | 0.96 | PARP1 (0.37) | PARP1PARP2HRH3MEN1KMT2A | |
| SCHEMBL7041380 | 0.88 | MEN1 (0.40) | PARP1MEN1KMT2AHSD11B1LMNA | |
| SCHEMBL7038516 | 0.85 | KMT2A (0.43) | PARP1MEN1KMT2AHSD11B1LMNA | |
| SCHEMBL7042034 | 0.84 | PRKCQ (0.39) | MEN1KMT2AHSD11B1 | |
| SCHEMBL7043722 | 0.84 | MEN1 (0.37) | PARP1MEN1KMT2A | |
| SCHEMBL7045615 | 0.84 | PARP1 (0.51) | PARP1PARP2HRH3 | |
| SCHEMBL7039979 | 0.83 | PARP1 (0.50) | PARP1PARP2MEN1KMT2A | |
| SCHEMBL5619928 | 0.82 | PARP1 (0.52) | PARP1PARP2 | |
| SCHEMBL7044651 | 0.81 | MEN1 (0.40) | MEN1KMT2ALMNAHTT | |
| SCHEMBL7041477 | 0.81 | DRD2 (0.44) | MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133477-B1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | ABBOTT GMBH & CO KG (DE) | 2004-02-18 | — | — | EP | disclosed |