Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | KLK7 | P49862 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NCF1 | P14598 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7044651 | 0.96 | MEN1 (0.40) | KMT2AMEN1LMNAHTTSMN1; SMN2 | |
| SCHEMBL7041380 | 0.89 | MEN1 (0.40) | KMT2AMEN1LMNAHTTSMN1; SMN2 | |
| SCHEMBL7042034 | 0.85 | PRKCQ (0.39) | KMT2AMEN1HSD11B1 | |
| SCHEMBL7044098 | 0.85 | PARP1 (0.38) | KMT2AMEN1LMNAHTTHSD11B1 | |
| SCHEMBL7043722 | 0.85 | MEN1 (0.37) | KMT2AMEN1PARP1 | |
| SCHEMBL7039979 | 0.84 | PARP1 (0.50) | KMT2AMEN1MAPTKDM4EPARP1 | |
| SCHEMBL5621361 | 0.82 | PARP1 (0.52) | KMT2AMEN1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL7043195 | 0.81 | PARP1 (0.37) | KMT2AMEN1HSD11B1PARP1 | |
| SCHEMBL7041477 | 0.81 | DRD2 (0.44) | KMT2AMEN1LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL7043340 | 0.81 | CHRNB2 (0.39) | KMT2AMEN1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133477-B1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | ABBOTT GMBH & CO KG (DE) | 2004-02-18 | — | — | EP | disclosed |