Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7762520 | 0.92 | JAK2 (0.48) | HPGDSMN1; SMN2PDE4DJAK2KDM4E | |
| SCHEMBL7766251 | 0.88 | SMN1; SMN2 (0.47) | HPGDSMN1; SMN2PDE4DJAK2HSD17B10 | |
| SCHEMBL7142931 | 0.88 | PDE4D (0.51) | HPGDSMN1; SMN2PDE4DKDM4EALDH1A1 | |
| SCHEMBL6871450 | 0.86 | SMN1; SMN2 (0.45) | HPGDSMN1; SMN2PDE4DJAK2HSD17B10 | |
| SCHEMBL7762456 | 0.86 | SMN1; SMN2 (0.45) | SMN1; SMN2PDE4DJAK2MAPT | |
| SCHEMBL7146644 | 0.86 | SMN1; SMN2 (0.53) | HPGDSMN1; SMN2PDE4DHSD17B10KDM4E | |
| SCHEMBL7762663 | 0.85 | PDE4D (0.57) | SMN1; SMN2PDE4DALDH1A1MAPT | |
| SCHEMBL7766283 | 0.85 | FYN (0.47) | SMN1; SMN2PDE4DKDM4ENPSR1 | |
| SCHEMBL7765386 | 0.84 | JAK2 (0.45) | HPGDSMN1; SMN2PDE4DJAK2KDM4E | |
| SCHEMBL6871008 | 0.83 | JAK2 (0.51) | SMN1; SMN2PDE4DJAK2CFTRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1412352-A1 | 8-METHOXY-(1,2,4)TRIAZOLO(1,5-A)PYRIDINE DERIVATIVES AND THEIR USE AS ADENOSINE RECEPTOR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-04-28 | — | — | EP | claimed |
| WO-2003010167-A1 | 8-METHOXY-(1,2,4)TRIAZOLO(1,5-A)PYRIDINE DERIVATIVES AND THEIR USE AS ADENOSINE RECEPTOR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-02-06 | — | — | WO | claimed |