Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 11/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7762663 | 0.90 | PDE4D (0.57) | FYNPDE4DSMN1; SMN2POLB | |
| SCHEMBL7766251 | 0.89 | SMN1; SMN2 (0.47) | PDE4DSMN1; SMN2POLBRXFP1 | |
| SCHEMBL7762520 | 0.89 | JAK2 (0.48) | FYNPDE4DSMN1; SMN2KDM4E | |
| SCHEMBL7762456 | 0.88 | SMN1; SMN2 (0.45) | PDE4DSMN1; SMN2DYRK3DYRK1ADYRK2 | |
| SCHEMBL6871450 | 0.88 | SMN1; SMN2 (0.45) | FYNPDE4DSMN1; SMN2KDM4EPOLB | |
| SCHEMBL7146644 | 0.87 | SMN1; SMN2 (0.53) | PDE4DSMN1; SMN2KDM4EPOLBRXFP1 | |
| SCHEMBL7765386 | 0.85 | JAK2 (0.45) | FYNPDE4DSMN1; SMN2KDM4EDYRK3 | |
| SCHEMBL7044503 | 0.85 | HPGD (0.43) | PDE4DSMN1; SMN2KDM4ENPSR1 | |
| SCHEMBL7142931 | 0.84 | PDE4D (0.51) | PDE4DSMN1; SMN2KDM4EPOLBRXFP1 | |
| SCHEMBL7765412 | 0.84 | SMN1; SMN2 (0.47) | PDE4DSMN1; SMN2KDM4EPOLBNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514989-B1 | Has a good affinity to the adenosine receptor and can therefore be used for the treatment or protection of diseases mediated by this receptor | HOFFMANN-LA ROCHE INC. | 2003-02-04 | — | — | US | disclosed |
| US-6514989-B1 | Has a good affinity to the adenosine receptor and can therefore be used for the treatment or protection of diseases mediated by this receptor | HOFFMANN-LA ROCHE INC. | 2003-02-04 | — | — | US | disclosed |