Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 9/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 2/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7762663 | 0.90 | PDE4D (0.57) | PDE4DMAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL7044503 | 0.88 | HPGD (0.43) | PDE4DMAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7766251 | 0.87 | SMN1; SMN2 (0.47) | PDE4DMAPTTP53SMN1; SMN2HPGD | |
| SCHEMBL7762520 | 0.86 | JAK2 (0.48) | PDE4DMAPTSMN1; SMN2KDM4EHPGD | |
| SCHEMBL6871450 | 0.85 | SMN1; SMN2 (0.45) | PDE4DMAPTTP53SMN1; SMN2KDM4E | |
| SCHEMBL7762456 | 0.85 | SMN1; SMN2 (0.45) | PDE4DMAPTSMN1; SMN2KMT2ADYRK3 | |
| SCHEMBL7146644 | 0.85 | SMN1; SMN2 (0.53) | PDE4DMAPTTP53SMN1; SMN2KDM4E | |
| SCHEMBL7143130 | 0.85 | PDE4D (0.52) | PDE4DMAPTKDM4ELMNABRAF | |
| SCHEMBL7765386 | 0.85 | JAK2 (0.45) | PDE4DMAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7766283 | 0.84 | FYN (0.47) | PDE4DSMN1; SMN2KDM4EDYRK3CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514989-B1 | Has a good affinity to the adenosine receptor and can therefore be used for the treatment or protection of diseases mediated by this receptor | HOFFMANN-LA ROCHE INC. | 2003-02-04 | — | — | US | disclosed |
| US-6514989-B1 | Has a good affinity to the adenosine receptor and can therefore be used for the treatment or protection of diseases mediated by this receptor | HOFFMANN-LA ROCHE INC. | 2003-02-04 | — | — | US | disclosed |
| US-6514989-B1 | Has a good affinity to the adenosine receptor and can therefore be used for the treatment or protection of diseases mediated by this receptor | HOFFMANN-LA ROCHE INC. | 2003-02-04 | — | — | US | disclosed |