Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7046802 | 0.68 | PIK3CD (0.40) | PIK3CDPIK3CAPIK3CBALDH1A1KDM4E | |
| SCHEMBL9761231 | 0.67 | ALDH1A1 (0.41) | ALDH1A1MAPTSMN1; SMN2LMNAKMT2A | |
| SCHEMBL9762260 | 0.65 | ALDH1A1 (0.41) | PIK3CDPIK3CAPIK3CBALDH1A1KDM4E | |
| SCHEMBL25380055 | 0.63 | KDM4E (0.42) | PIK3CDPIK3CAPIK3CBALDH1A1KDM4E | |
| SCHEMBL15880606 | 0.63 | GRAMD1A (0.48) | PIK3CDPIK3CAPIK3CBKDM4EMAPT | |
| SCHEMBL9761837 | 0.63 | CYP1A2 (0.43) | ALDH1A1MAPTSMN1; SMN2GAALMNA | |
| SCHEMBL9762538 | 0.62 | SMN1; SMN2 (0.38) | PIK3CDPIK3CAPIK3CBALDH1A1KDM4E | |
| SCHEMBL15356842 | 0.60 | ALDH1A1 (0.48) | PIK3CDPIK3CAPIK3CBALDH1A1KDM4E | |
| SCHEMBL18282525 | 0.60 | MAPT (0.52) | ALDH1A1MAPTSMN1; SMN2LMNAKMT2A | |
| SCHEMBL9761506 | 0.60 | KMT2A (0.39) | ALDH1A1KDM4EMAPTSMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850224-B1 | RADIATION-ACTIVATED CYTOTOXIN THERAPY | AUCKLAND UNISERVICES LTD (NZ) | 2003-04-09 | — | — | EP | disclosed |
| EP-1225169-A1 | Radiation-activated cytotoxin therapy | AUCKLAND UNISERVICES LIMITED (NZ) | 2002-07-24 | — | — | EP | disclosed |
| US-6071908-A | A RADIATION-ACTIVATED CYTOTOXIN PRODRUG HAVING LOW TOXICITY, WHICH CAN BE REDUCED BY REDUCING AGENTS GENERATED BY THE RADIOLYSIS OF WATER WHICH RELEASES AN CYTOXIC EFFECTOR; ANTITUMOR,-CARCINOGENIC AGENTS; | AUCKLAND UNISERVICES LIMITED (NZ) | 2000-06-06 | — | — | US | disclosed |
| EP-0850224-A1 | RADIATION-ACTIVATED CYTOTOXIN THERAPY | AUCKLAND UNISERVICES LIMITED (NZ) | 1998-07-01 | — | — | EP | disclosed |
| WO-1997007101-A1 | RADIATION-ACTIVATED CYTOTOXIN THERAPY | AUCKLAND UNISERVICES LIMITED (NZ) | 1997-02-27 | — | — | WO | disclosed |