Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.54 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.54 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.54 |
| ▸ | LTA4H | P09960 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.50 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8326306 | 0.95 | LTA4H (0.53) | BRD4CYSLTR2CYSLTR1LTA4HMAPT | |
| SCHEMBL3170654 | 0.94 | LTA4H (0.52) | BRD4CYSLTR2CYSLTR1LTA4HMAPT | |
| SCHEMBL17266636 | 0.93 | MAPT (0.52) | BRD4CYSLTR2CYSLTR1LTA4HMAPT | |
| SCHEMBL6937314 | 0.87 | MEN1 (0.62) | BRD4CYSLTR2CYSLTR1LTA4HMAPT | |
| SCHEMBL8981963 | 0.85 | BRD4 (0.56) | BRD4CYSLTR2CYSLTR1LTA4HMAPT | |
| SCHEMBL3466988 | 0.85 | CYSLTR2 (0.59) | BRD4CYSLTR2CYSLTR1LTA4HMAPT | |
| SCHEMBL2653015 | 0.84 | LTA4H (0.56) | BRD4CYSLTR2CYSLTR1LTA4HMAPT | |
| SCHEMBL3267566 | 0.84 | BRD4 (0.54) | BRD4CYSLTR2CYSLTR1LTA4HMAPT | |
| SCHEMBL12549253 | 0.84 | LTA4H (0.59) | BRD4CYSLTR2CYSLTR1LTA4HMAPT | |
| SCHEMBL1623579 | 0.84 | BRD4 (0.54) | BRD4CYSLTR2CYSLTR1LTA4HMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004063169-A1 | HYDROXAMID ACID DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2004-07-29 | — | — | WO | disclosed |
| EP-0874808-B1 | BIPHENYL HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES | ABBOTT LAB (US) | 2003-04-09 | — | — | EP | disclosed |
| EP-0874808-A1 | BIPHENYL HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES | Abbott Laboratories (US) | 1998-11-04 | — | — | EP | disclosed |
| US-5665777-A | ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES (US) | 1997-09-09 | — | — | US | disclosed |
| WO-1997018188-A1 | BIPHENYL HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES | ABBOTT LABORATORIES (US) | 1997-05-22 | — | — | WO | disclosed |