Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.55 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.53 |
| ▸ | MGLL | Q99685 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.48 |
| ▸ | GPR34 | Q9UPC5 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.45 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7047874 | 0.86 | MMP3 (0.50) | FFAR4FFAR1HDAC1HDAC2GPR34 | |
| SCHEMBL7045826 | 0.81 | HDAC1 (0.58) | MRGPRX4FFAR4FFAR1HDAC1HDAC2 | |
| SCHEMBL7044314 | 0.81 | HDAC3 (0.49) | HDAC1HDAC2HDAC8HDAC6HPGD | |
| SCHEMBL7048468 | 0.78 | HDAC1 (0.64) | HDAC1HDAC2HDAC8HDAC6HDAC4 | |
| SCHEMBL7047498 | 0.76 | HDAC1 (0.68) | FFAR4FFAR1HDAC1HDAC2HDAC8 | |
| SCHEMBL7042844 | 0.75 | HDAC2 (0.58) | FFAR1HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL9191952 | 0.74 | HDAC3 (0.71) | HDAC1HDAC2HDAC8HDAC6HDAC3 | |
| SCHEMBL7046130 | 0.73 | FFAR4 (0.78) | FFAR4FFAR1HDAC1HDAC2HDAC8 | |
| SCHEMBL6763786 | 0.72 | HDAC3 (0.74) | HDAC1HDAC2HDAC8HDAC6HDAC3 | |
| SCHEMBL7044760 | 0.72 | HDAC1 (0.74) | HDAC1HDAC2HDAC8HDAC6HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874808-B1 | BIPHENYL HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES | ABBOTT LAB (US) | 2003-04-09 | — | — | EP | disclosed |
| EP-0874808-A1 | BIPHENYL HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES | Abbott Laboratories (US) | 1998-11-04 | — | — | EP | disclosed |
| US-5665777-A | ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES (US) | 1997-09-09 | — | — | US | disclosed |
| WO-1997018188-A1 | BIPHENYL HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES | ABBOTT LABORATORIES (US) | 1997-05-22 | — | — | WO | disclosed |