Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 5/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 2/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | REN | P00797 | 4/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | KLK7 | P49862 | 1/20 | 0.40 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13333366 | 1.00 | CACNA1B (0.43) | CACNA1BCYP3A4CYP2C9CYP2C19CTSL | |
| SCHEMBL7045269 | 0.91 | SLC15A1 (0.45) | CACNA1BCYP3A4CYP2C9CYP2C19CTSL | |
| SCHEMBL7045267 | 0.91 | SLC15A1 (0.45) | CACNA1BCYP3A4CYP2C9CYP2C19CTSL | |
| SCHEMBL5488362 | 0.87 | MMP1 (0.49) | CTSLCTSBCTSSCTSK | |
| SCHEMBL5488364 | 0.87 | MMP1 (0.49) | CTSLCTSBCTSSCTSK | |
| SCHEMBL3323186 | 0.84 | MMP2 (0.54) | CYP3A4CYP2C9CYP2C19CTSLCTSB | |
| SCHEMBL3323188 | 0.84 | MMP2 (0.54) | CYP3A4CYP2C9CYP2C19CTSLCTSB | |
| SCHEMBL1628776 | 0.83 | MMP2 (0.53) | CYP3A4CYP2C9CYP2C19CTSLCTSB | |
| SCHEMBL28638619 | 0.81 | SYK (0.45) | SYKUSP2 | |
| SCHEMBL7280308 | 0.81 | SLC15A1 (0.49) | CYP3A4CYP2C9CYP2C19ATMSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998454-B1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARM (GB) | 2003-03-26 | — | — | EP | disclosed |
| US-6358987-B1 | FOR THERAPY AND PROPHYLAXIS OF RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPENIAS SUCH AS OSTEOPOROSIS, PERIODONTITIS, GINGIVITIS, CORNEAL EPIDERMAL OR GASTRIC ULCERATION, AND TUMOUR METASTASIS, INVASION AND GROWTH | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 2002-03-19 | — | — | US | disclosed |
| US-6271262-B1 | AMIDESULFONAMIDE COMPOUNDS AS ENZYME INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 2001-08-07 | — | — | US | disclosed |