Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | CCR2 | P41597 | 10/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7048043 | 0.89 | BRD4 (0.44) | BRD4RAB9ACCR2LMNAMAPT | |
| SCHEMBL7049658 | 0.85 | BRD4 (0.50) | BRD4RAB9ACCR2LMNAMAPT | |
| SCHEMBL7045478 | 0.82 | HDAC1 (0.47) | BRD4RAB9ANPC1CCR2LMNA | |
| SCHEMBL7052377 | 0.81 | CCR2 (0.53) | BRD4RAB9ACCR2LMNAMAPT | |
| SCHEMBL7947149 | 0.80 | BRD4 (0.46) | BRD4RAB9ACCR2LMNAMAPT | |
| SCHEMBL7047693 | 0.74 | CCR2 (0.48) | CCR2 | |
| SCHEMBL7050825 | 0.72 | CCR2 (0.39) | RAB9ANPC1CCR2LMNAMAPT | |
| SCHEMBL7050842 | 0.70 | HDAC1 (0.48) | RAB9ACCR2LMNAMAPTHDAC1 | |
| SCHEMBL7049651 | 0.70 | RAB9A (0.48) | BRD4RAB9ANPC1CCR2LMNA | |
| SCHEMBL7047624 | 0.69 | CCR2 (0.39) | CCR2LMNAMAPTSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054667-B1 | BICYCLIC PYRROLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS ANTIINFLAMMATORY AND IMMUNOMODULATING AGENTS | ASTRAZENECA UK LTD (GB) | 2003-04-16 | — | — | EP | disclosed |
| US-6291507-B1 | INHIBITOR OF MONOCYTE CHEMOATTRACTANT PROTEIN-1; INDOLE DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 2001-09-18 | — | — | US | disclosed |