Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD1 | Q15139 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7045097 | 0.85 | SLC40A1 (0.49) | PRKD1HTR2CHTR2ASLC6A4GLO1 | |
| SCHEMBL1379328 | 0.85 | TDP1 (0.50) | PRKD1HTTLMNAHTR6 | |
| SCHEMBL3619544 | 0.84 | PRKD1 (0.44) | PRKD1HTR2CHTR2ASLC6A4GLO1 | |
| SCHEMBL1380902 | 0.84 | GLO1 (0.51) | PRKD1HTR2CHTR2ASLC6A4GLO1 | |
| SCHEMBL3616470 | 0.83 | MEN1 (0.50) | PRKD1HTR2CHTR2ASLC6A4ALOX15 | |
| SCHEMBL1380555 | 0.82 | NFKBIA (0.51) | PRKD1HTR2CHTR2ASLC6A4ALOX15 | |
| SCHEMBL3616367 | 0.82 | HTR6 (0.51) | PRKD1HTR2CHTR2ASLC6A4CYP3A4 | |
| SCHEMBL10571731 | 0.81 | PRKD1 (0.49) | PRKD1HTR2CHTR2ASLC6A4EPHX2 | |
| SCHEMBL3627476 | 0.81 | MEN1 (0.53) | MAPK1HTR6HTR7 | |
| SCHEMBL1377405 | 0.80 | SLC40A1 (0.54) | PRKD1CYP3A4HTR6HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1412325-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS, PROCESS FOR THEIR USE AS MEDICAMENT FOR THE TREATMENT OF CNS DISORDERS, OBESITY AND TYPE II DIABETES | BIOVITRUM AB (SE) | 2004-04-28 | — | — | EP | disclosed |
| WO-2002100822-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS, PROCESS FOR THEIR USE AS MEDICAMENT FOR THE TREATMENT OF CNS DISORDERS, OBESITY AND TYPE II DIABETES | BIOVITRUM AB (SE) | 2002-12-19 | — | — | WO | disclosed |