Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPMT | P51580 | 2/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.39 |
| ▸ | GCK | P35557 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.38 |
| ▸ | PPARG | P37231 | 3/20 | 0.38 |
| ▸ | PTGES | O14684 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | THRA | P10827 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6720844 | 0.85 | THRA (0.51) | TPMTTHRATHRBXDH | |
| SCHEMBL8812450 | 0.80 | NFE2L2 (0.44) | CXCR2NFE2L2ALOX5PPARGSCN9A | |
| SCHEMBL28314163 | 0.77 | TPMT (0.49) | TPMTTHRATHRBPLAU | |
| SCHEMBL26828022 | 0.76 | TPMT (0.52) | TPMTTHRATHRBPLAU | |
| SCHEMBL12420721 | 0.75 | GCK (0.47) | NFE2L2KDM4CGCKALOX5PTGES | |
| SCHEMBL7316232 | 0.75 | NFE2L2 (0.62) | NFE2L2GCKL3MBTL1HPGD | |
| SCHEMBL2193712 | 0.73 | KMT2A (0.58) | NFE2L2GCKRAB9AHPGD | |
| SCHEMBL12420822 | 0.72 | NPC1 (0.54) | NFE2L2KDM4CGCKNPC1RAB9A | |
| SCHEMBL2195324 | 0.72 | KDM4C (0.54) | NFE2L2KDM4CGCKNPC1RAB9A | |
| SCHEMBL11893098 | 0.71 | CXCR2 (0.42) | CXCR2NFE2L2NPC1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003009871-A2 | INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR FOR DECREASING BODY MASS | GENSET S.A. (FR) | 2003-02-06 | — | — | WO | disclosed |