Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 2/20 | 0.51 |
| ▸ | PARP10 | Q53GL7 | 5/20 | 0.46 |
| ▸ | PARP15 | Q460N3 | 4/20 | 0.46 |
| ▸ | XDH | P47989 | 2/20 | 0.44 |
| ▸ | RHEB | Q15382 | 1/20 | 0.44 |
| ▸ | TPMT | P51580 | 2/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7045585 | 0.85 | TPMT (0.41) | THRATHRBXDHTPMT | |
| SCHEMBL7045808 | 0.79 | RAB9A (0.46) | — | |
| SCHEMBL8811665 | 0.79 | THRA (0.42) | THRATHRBPARP10PARP15RHEB | |
| SCHEMBL1532862 | 0.73 | PARP10 (0.74) | PARP10PARP15MAP4K4PARP2CCNA2 | |
| SCHEMBL1532841 | 0.73 | PARP10 (0.74) | PARP10PARP15MAP4K4PARP2CCNA2 | |
| SCHEMBL12420700 | 0.73 | PARP10 (0.74) | PARP10PARP15MAP4K4PARP2CCNA2 | |
| SCHEMBL15968953 | 0.73 | FFAR4 (0.48) | THRATHRBPARP10PARP15PARP2 | |
| SCHEMBL31325672 | 0.73 | NR1H4 (0.48) | PARP10PARP15XDHMAP4K4PARP2 | |
| SCHEMBL28314163 | 0.72 | TPMT (0.49) | THRATHRBTPMT | |
| SCHEMBL26828022 | 0.72 | TPMT (0.52) | THRATHRBTPMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6677473-B1 | TREATMENT, PREVENTION OR AMELIORATION OF ONE OR MORE SYMPTOMS OF THROMBOTIC DISORDERS, UNSTABLE ANGINA OR CANCER | CORVAS INTERNATIONAL INC | 2004-01-13 | — | — | US | disclosed |
| WO-2001036351-A2 | PLASMINOGEN ACTIVATOR INHIBITOR ANTAGONISTS RELATED APPLICATIONS | CORVAS INTERNATIONAL, INC. (US) | 2001-05-25 | — | — | WO | disclosed |