Dyrene

Dyrene

SCHEMBL7045805

C=Cc1ccccc1.Clc1nc(Cl)nc(Nc2ccccc2Cl)n1

nearest known ligand 0.73

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 2/20 0.73
▸ NFKB1 P19838 1/20 0.49
▸ MAPT P10636 5/20 0.45
▸ KMT2A Q03164 4/20 0.45
▸ MEN1 O00255 1/20 0.45
▸ MAPK1 P28482 1/20 0.45
▸ IGF1R P08069 2/20 0.44
▸ ALDH1A1 P00352 3/20 0.44
▸ KDM4E B2RXH2 2/20 0.44
▸ SMN1; SMN2 Q16637 2/20 0.44
▸ RAD52 P43351 1/20 0.44
▸ NPSR1 Q6W5P4 2/20 0.43
▸ AURKA O14965 1/20 0.41
▸ NPC1 O15118 1/20 0.40
▸ RAB9A P51151 1/20 0.40
▸ LMNA P02545 1/20 0.40
▸ ULK1 O75385 1/20 0.39
▸ PDE5A O76074 1/20 0.38
▸ HDAC3 O15379 1/20 0.38
▸ HDAC1 Q13547 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dyrene SCHEMBL2065280 0.88 TSHR (0.77) TSHRNFKB1MAPTKMT2AMEN1
Dyrene SCHEMBL6750152 0.85 TSHR (1.00) TSHRNFKB1MAPTKMT2AMEN1
Dyrene SCHEMBL133054 0.85 TSHR (1.00) TSHRNFKB1MAPTKMT2AMEN1
Dyrene SCHEMBL13280 0.85 TSHR (1.00) TSHRNFKB1MAPTKMT2AMEN1
Dyrene SCHEMBL8166670 0.85 TSHR (1.00) TSHRNFKB1MAPTKMT2AMEN1
Dyrene SCHEMBL29364667 0.85 TSHR (1.00) TSHRNFKB1MAPTKMT2AMEN1
Dyrene SCHEMBL1903290 0.85 TSHR (1.00) TSHRNFKB1MAPTKMT2AMEN1
Dyrene SCHEMBL1254529 0.84 TSHR (0.89) TSHRNFKB1MAPTKMT2AMEN1
Dyrene SCHEMBL11351922 0.84 TSHR (0.89) TSHRNFKB1MAPTKMT2AMEN1
Dyrene SCHEMBL1191351 0.84 TSHR (0.71) TSHRNFKB1MAPTKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117779516-A Preparation method of base paper for waterproof and oilproof coating paperboard 山东世纪阳光纸业集团有限公司 2024-03-29 — — CN disclosed
EP-0733941-B1 Reduction of the sensitometric toe area of photographic films EASTMAN KODAK CO (US) 2003-04-16 — — EP disclosed
US-6087080-A COMPRISING INFRARED SPECTRALLY SENSITIZED NEGATIVE-ACTING SILVER HALIDE PHOTOGRAPHIC ELEMENT COMPRISING A HYDROPHILIC COLLOIDAL BINDER CONTAINING SILVER HALIDE EMULSION AND AN ANTHRAQUINONE; QUALITY MINNESOTA MINING & MANUFACTURING COMPANY (US) 2000-07-11 — — US disclosed
US-5922527-A A BLACK AND WHITE, NEGATIVE-ACTING, SILVER BROMIDE PHOTOGRAPHIC EMULSION COMPRISES A DITHIO SUBSTITUTED TONING AGENT IMATION CORP. (US) 1999-07-13 — — US disclosed
EP-0912915-A1 IMAGE TONERS FOR SILVER HALIDE PHOTOGRAPHIC FILMS Imation Corp. (US) 1999-05-06 — — EP disclosed
WO-1998002779-A1 IMAGE TONERS FOR SILVER HALIDE PHOTOGRAPHIC FILMS IMATION CORP. (US) 1998-01-22 — — WO disclosed
EP-0733941-A1 Reduction of the sensitometric toe area of photographic films MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1996-09-25 — — EP disclosed
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