SCHEMBL7046111

SCHEMBL7046111

CC(=Cc1ccc(Br)cc1C=C(C)C(=O)NC(=N)N)C(=O)NC(=N)N

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC9A3 P48764 2/20 0.40
SLC9A1 P19634 1/20 0.40
KDM4E B2RXH2 3/20 0.38
KMT2A Q03164 3/20 0.38
GAA P10253 2/20 0.38
NPC1 O15118 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
RAB9A P51151 1/20 0.34
DYRK1A Q13627 1/20 0.34
MAPT P10636 4/20 0.33
POLB P06746 1/20 0.33
ERN1 O75460 1/20 0.33
ALDH1A1 P00352 4/20 0.33
DHODH Q02127 1/20 0.32
MEN1 O00255 1/20 0.32
F2 P00734 1/20 0.32
F10 P00742 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7046107 1.00 SLC9A3 (0.40) SLC9A3SLC9A1KDM4EKMT2AGAA
SCHEMBL1277314 0.90 KMT2A (0.34) SLC9A3SLC9A1KDM4EKMT2AGAA
SCHEMBL1277925 0.89 SLC9A3 (0.36) SLC9A3SLC9A1KDM4EKMT2AGAA
SCHEMBL1277382 0.80 KMT2A (0.40) KDM4EKMT2ANPC1CYP1A2CYP2C9
SCHEMBL1277291 0.80 SLC9A3 (0.45) SLC9A3SLC9A1KDM4EKMT2AGAA
SCHEMBL1277255 0.78 HSD11B1 (0.40) KMT2AGAANPC1RAB9AMAPT
Hydrochloric Acid SCHEMBL1949384 0.76 SLC9A3 (0.65) SLC9A3SLC9A1KDM4ENPC1RAB9A
SCHEMBL8375716 0.74 SLC9A1 (0.54) SLC9A3SLC9A1KMT2ANPC1RAB9A
SCHEMBL8375706 0.74 SLC9A1 (0.54) SLC9A3SLC9A1KMT2ANPC1RAB9A
SCHEMBL19341349 0.73 CA1 (0.43) KMT2ANPC1RAB9AMAPTPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1124841-B1 SUBSTITUTED PHENYL ALKENOYL GUANIDINES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS MEDICAMENTS OR DIAGNOSTIC AGENTS AND MEDICAMENTS THAT CONTAIN THEM AVENTIS PHARMA GMBH (DE) 2003-04-02 EP disclosed
EP-1124841-A1 BILE-ACID SUBSTITUTED PHENYL ALKENOYL GUANIDINES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS MEDICAMENTS OR DIAGNOSTIC AGENTS AND MEDICAMENTS THAT CONTAIN THEM Aventis Pharma Deutschland GmbH (DE) 2001-08-22 EP disclosed
US-6166002-A Substituted phenylalkenoylguanidines, process for their preparation, and their use in medicaments and in diagnostics AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2000-12-26 US disclosed
WO-2000024761-A1 BILE-ACID SUBSTITUTED PHENYL ALKENOYL GUANIDINES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS MEDICAMENTS OR DIAGNOSTIC AGENTS AND MEDICAMENTS THAT CONTAIN THEM AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2000-05-04 WO disclosed