Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 2/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | CCR2 | P41597 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19534246 | 0.88 | CYP19A1 (0.40) | CYP19A1HSD11B1 | |
| SCHEMBL6730153 | 0.83 | GRIN1 (0.38) | GRIN1GRIN2ACYP19A1HSD11B1 | |
| SCHEMBL28358676 | 0.82 | CYP19A1 (0.43) | CYP19A1CCR2 | |
| SCHEMBL11196121 | 0.77 | CYP19A1 (0.36) | GRIN1GRIN2ACYP19A1HSD11B1CYP2D6 | |
| SCHEMBL3272687 | 0.74 | GRIN1 (0.33) | GRIN1GRIN2A | |
| SCHEMBL21585193 | 0.74 | POLB (0.36) | CYP19A1HSD11B1 | |
| SCHEMBL14378012 | 0.73 | MMP9 (0.33) | GRIN1GRIN2ACCR2 | |
| SCHEMBL22213505 | 0.72 | CYP19A1 (0.38) | GRIN1GRIN2ACYP19A1CCR2 | |
| SCHEMBL28870336 | 0.72 | CCR2 (0.33) | GRIN1GRIN2ACYP19A1CCR2 | |
| SCHEMBL9800283 | 0.71 | GRIN1 (0.33) | GRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003007940-A1 | LACTAM AND THIOLACTAM DERIVATIVES AS ANESTHETIC AND CONSCIOUS SEDATION AGENTS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2003-01-30 | — | — | WO | disclosed |
| US-5003082-A | Reacting a lactam with hydrogen sulfide in the presence of an inorganic catalyst | PHILLIPS PETROLEUM COMPANY (US) | 1991-03-26 | — | — | US | disclosed |
| US-4990628-A | Reacting lactam with hydrogen sulfide in presence of group 8 metals or compounds on alumina; support; sulfiding | PHILLIPS PETROLEUM COMPANY (US) | 1991-02-05 | — | — | US | disclosed |
| US-4956476-A | Catalytic reaction of a lactam with hydrogen sulfide to produce a thiolactam, alumina is the catalyst | PHILLIPS PETROLEUM COMPANY (US) | 1990-09-11 | — | — | US | disclosed |
| US-4145352-A | SULFACTIVE CATALYST | PHILLIPS PETROLEUM COMPANY (US) | 1979-03-20 | — | — | US | disclosed |