Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
| ▸ | TERT | O14746 | 1/20 | 0.48 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA3 | P07451 | 1/20 | 0.37 |
| ▸ | CA6 | P23280 | 1/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7044936 | 0.94 | CYP2A6 (0.47) | CYP2A6TERTTLR9PTGS2CA12 | |
| SCHEMBL11398927 | 0.94 | CYP2A6 (0.47) | CYP2A6TERTTLR9PTGS2CA12 | |
| SCHEMBL1323372 | 0.87 | CHAT (0.47) | CYP2A6TERTGAAPTGS2HDAC8 | |
| SCHEMBL1001154 | 0.86 | TERT (0.55) | TERTTLR9GAACA12CA2 | |
| Water SCHEMBL25192063 | 0.85 | CHAT (0.46) | CYP2A6TERTGAAPTGS2HDAC8 | |
| SCHEMBL9079626 | 0.85 | HDAC8 (0.58) | TERTTLR9GAAPTGS2CA12 | |
| SCHEMBL372527 | 0.83 | CHAT (0.61) | TERTPTGS2HTTSMN1; SMN2MEN1 | |
| SCHEMBL4625614 | 0.83 | CYP2A6 (0.44) | CYP2A6TERTTLR9GAAPTGS2 | |
| Paraquat SCHEMBL4086035 | 0.82 | TERT (0.59) | TERTTLR9GAACA12CA2 | |
| SCHEMBL4688796 | 0.80 | TERT (0.43) | TERTPTGS2CA12CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1300132-A2 | Agent for dyeing keratinous fibres | Henkel Kommanditgesellschaft auf Aktien (DE) | 2003-04-09 | — | — | EP | claimed |
| EP-0906262-B1 | COLCHICINE-SKELETON COMPOUNDS, THEIR USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM | INDENA SPA (IT) | 2002-08-14 | — | — | EP | claimed |
| US-6080739-A | HAVE A MARKED ANTIBLASTIC ACTIVITY BOTH ON THE NORMAL CANCER CELLS AND ON THE CHEMORESISTANT PHENOTYPE | INDENA S.P.A. (IT) | 2000-06-27 | — | — | US | claimed |
| EP-0906262-A1 | COLCHICINE-SKELETON COMPOUNDS, THEIR USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM | INDENA S.p.A. (IT) | 1999-04-07 | — | — | EP | claimed |
| WO-1997047577-A1 | COLCHICINE-SKELETON COMPOUNDS, THEIR USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM | INDENA S.P.A. (IT) | 1997-12-18 | — | — | WO | claimed |
| EP-3665528-B1 | ELECTRO-OPTICAL DEVICE HAVING A TRANSPARENT ION EXCHANGE MEMBRANE | GENTEX CORP (US) | 2023-04-05 | — | — | EP | disclosed |
| CN-110892320-B | Electro-optical device with transparent ion exchange membrane | 金泰克斯公司 | 2022-05-10 | — | — | CN | disclosed |
| US-10774191-B2 | Electro-optical device having a transparent ion exchange membrane | GENTEX CORPORATION (US) | 2020-09-15 | — | — | US | disclosed |
| EP-3665528-A1 | ELECTRO-OPTICAL DEVICE HAVING A TRANSPARENT ION EXCHANGE MEMBRANE | Gentex Corporation (US) | 2020-06-17 | — | — | EP | disclosed |
| CN-110892320-A | Electro-optical device with transparent ion exchange membrane | 金泰克斯公司 | 2020-03-17 | — | — | CN | disclosed |
| US-20190048159-A1 | ELECTRO-OPTICAL DEVICE HAVING A TRANSPARENT ION EXCHANGE MEMBRANE | GENTEX CORPORATION | 2019-02-14 | — | — | US | disclosed |
| WO-2019032695-A1 | ELECTRO-OPTICAL DEVICE HAVING A TRANSPARENT ION EXCHANGE MEMBRANE | GENTEX CORPORATION (US) | 2019-02-14 | — | — | WO | disclosed |
| EP-1300132-A2 | Agent for dyeing keratinous fibres | Henkel Kommanditgesellschaft auf Aktien (DE) | 2003-04-09 | — | — | EP | disclosed |
| EP-0906262-B1 | COLCHICINE-SKELETON COMPOUNDS, THEIR USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM | INDENA SPA (IT) | 2002-08-14 | — | — | EP | disclosed |
| US-6080739-A | HAVE A MARKED ANTIBLASTIC ACTIVITY BOTH ON THE NORMAL CANCER CELLS AND ON THE CHEMORESISTANT PHENOTYPE | INDENA S.P.A. (IT) | 2000-06-27 | — | — | US | disclosed |
| EP-0906262-A1 | COLCHICINE-SKELETON COMPOUNDS, THEIR USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM | INDENA S.p.A. (IT) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997047577-A1 | COLCHICINE-SKELETON COMPOUNDS, THEIR USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM | INDENA S.P.A. (IT) | 1997-12-18 | — | — | WO | disclosed |