Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | CHAT | P28329 | 2/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10614065 | 0.89 | LMNA (0.49) | TERTRAB9AMAPTPOLBMAOB | |
| SCHEMBL11398927 | 0.87 | CYP2A6 (0.47) | TERTRAB9AMAPTPOLBPTGS2 | |
| SCHEMBL7044936 | 0.87 | CYP2A6 (0.47) | TERTRAB9AMAPTPOLBPTGS2 | |
| SCHEMBL372527 | 0.85 | CHAT (0.61) | TERTRAB9AMAPTPOLBPTGS2 | |
| SCHEMBL531126 | 0.83 | MEN1 (0.63) | TERTRAB9AMAPTPOLBALDH1A1 | |
| SCHEMBL531127 | 0.83 | MEN1 (0.63) | TERTRAB9AMAPTPOLBALDH1A1 | |
| SCHEMBL10968004 | 0.83 | TERT (0.46) | TERTRAB9AMAPTPOLBPTGS2 | |
| SCHEMBL7047125 | 0.80 | CYP2A6 (0.48) | TERTRAB9AMAPTPTGS2KDM4E | |
| SCHEMBL6318506 | 0.80 | MEN1 (0.47) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL1001154 | 0.79 | TERT (0.55) | TERTMAPTALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1161555-B1 | 4-(4-HYDROXYSTYRYL)PYRIDINE-CONTAINING SUBSTRATES FOR AN ANALYTE DEPENDENT ENZYME ACTIVATION SYSTEM | PERKINELMER LAS INC (US) | 2008-01-02 | — | — | EP | disclosed |
| EP-1161555-A4 | 4-(4-HYDROXYSTYRYL)PYRIDINE-CONTAINING SUBSTRATES FOR AN ANALYTE DEPENDENT ENZYME ACTIVATION SYSTEM | NEN LIFE SCIENCE PROD INC (US) | 2004-12-22 | — | — | EP | disclosed |
| US-6355443-B1 | 4-(4-hydroxystyryl) pyridine-containing substrates for an analyte dependent enzyme activation system | BOBROW MARK NORMAN (US) | 2002-03-12 | — | — | US | disclosed |
| WO-2000055358-A9 | 4-(4-HYDROXYSTYRYL)PYRIDINE-CONTAINING SUBSTRATES FOR AN ANALYTE DEPENDENT ENZYME ACTIVATION SYSTEM | NEN LIFE SCIENCE PROD INC (US) | 2002-01-03 | — | — | WO | disclosed |
| EP-1161555-A1 | 4-(4-HYDROXYSTYRYL)PYRIDINE-CONTAINING SUBSTRATES FOR AN ANALYTE DEPENDENT ENZYME ACTIVATION SYSTEM | NEN Life Science Products, Inc. (US) | 2001-12-12 | — | — | EP | disclosed |
| WO-2000055358-A1 | 4-(4-HYDROXYSTYRYL)PYRIDINE-CONTAINING SUBSTRATES FOR AN ANALYTE DEPENDENT ENZYME ACTIVATION SYSTEM | NEN LIFE SCIENCE PRODUCTS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |