Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | MTTP | P55157 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | MTR | Q99707 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7053021 | 0.89 | SIGMAR1 (0.46) | HSD11B1SIGMAR1HRH2HRH1MTTP | |
| SCHEMBL7051788 | 0.88 | SIGMAR1 (0.43) | HSD11B1SIGMAR1HRH2HRH1SMN1; SMN2 | |
| SCHEMBL7047133 | 0.86 | SIGMAR1 (0.50) | HSD11B1SIGMAR1HRH2HRH1MTTP | |
| SCHEMBL7049326 | 0.82 | HSD11B1 (0.52) | HSD11B1SIGMAR1HRH2HRH1SMN1; SMN2 | |
| SCHEMBL7047136 | 0.81 | SIGMAR1 (0.43) | HSD11B1SIGMAR1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL7047217 | 0.81 | SIGMAR1 (0.48) | HSD11B1SIGMAR1HRH2HRH1MTTP | |
| Hydrochloric Acid SCHEMBL7051147 | 0.81 | HSD11B1 (0.51) | HSD11B1SIGMAR1HRH2HRH1SMN1; SMN2 | |
| SCHEMBL7052018 | 0.81 | SIGMAR1 (0.43) | HSD11B1SIGMAR1HRH2HRH1SMN1; SMN2 | |
| SCHEMBL7051141 | 0.81 | SIGMAR1 (0.50) | HSD11B1SIGMAR1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL7051784 | 0.81 | SIGMAR1 (0.52) | HSD11B1SIGMAR1HRH2HRH1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030114442-A1 | Substituted piperazine derivatives as mtp inhibitors | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030114442-A1 | Substituted piperazine derivatives as mtp inhibitors | MTTP, CETP, LIPC | HSD11B1 1161/4885SIGMAR1 671/4885HRH2 1435/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.