Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6383642 | 0.84 | ADRA1A (0.51) | ADRA1AOPRL1ALDH1A1HSD17B10KDM4E | |
| SCHEMBL161548 | 0.84 | ADRA1A (0.51) | ADRA1AOPRL1ALDH1A1HSD17B10KDM4E | |
| SCHEMBL3671551 | 0.82 | POLB (0.42) | ALDH1A1HSD17B10CYP2C9PIN1PTGDR2 | |
| Hydrochloric Acid SCHEMBL30170745 | 0.82 | ADRA1A (0.50) | ADRA1AOPRL1ALDH1A1HSD17B10KDM4E | |
| SCHEMBL7357951 | 0.79 | ALDH1A1 (0.41) | ALDH1A1HSD17B10MAPTTSHRPIN1 | |
| SCHEMBL30975812 | 0.79 | RBP4 (0.39) | ALDH1A1HSD17B10CYP2C9PIN1PTGDR2 | |
| SCHEMBL31557088 | 0.78 | ADRA1A (0.47) | ADRA1AOPRL1ALDH1A1HSD17B10KDM4E | |
| SCHEMBL4694491 | 0.78 | ADRA1A (0.47) | ADRA1AOPRL1ALDH1A1HSD17B10KDM4E | |
| SCHEMBL4443007 | 0.78 | SLC6A2 (0.40) | ADRA1AALDH1A1HSD17B10CYP2C9PIN1 | |
| SCHEMBL10457353 | 0.78 | ALDH1A1 (0.54) | ALDH1A1KDM4EMAPTHPGDCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1299377-A2 | SPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 2003-04-09 | — | — | EP | disclosed |
| WO-2002000641-A2 | SPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 2002-01-03 | — | — | WO | disclosed |