Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.35 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.35 |
| ▸ | FABP4 | P15090 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7051176 | 0.86 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DTSHR | |
| SCHEMBL7054012 | 0.84 | IKBKB (0.39) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7052278 | 0.84 | PDE4D (0.52) | PDE4APDE4BPDE4CPDE4DMKNK2 | |
| SCHEMBL7402562 | 0.81 | CYP1A1 (0.39) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7056722 | 0.80 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DLMNA | |
| O-Tolylamine SCHEMBL7366469 | 0.80 | IKBKB (0.38) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7052699 | 0.80 | IKBKB (0.45) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7055267 | 0.80 | LMNA (0.40) | PDE4APDE4BPDE4CPDE4DTSHR | |
| SCHEMBL7051026 | 0.78 | POLB (0.42) | PDE4APDE4BPDE4CPDE4DTSHR | |
| SCHEMBL7055258 | 0.78 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901482-B1 | BENZOFURAN CARBOXAMIDES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2003-05-02 | — | — | EP | disclosed |