Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7402562 | 0.95 | CYP1A1 (0.39) | PDE4APDE4BPDE4CPDE4DCYP1A1 | |
| SCHEMBL7052699 | 0.90 | IKBKB (0.45) | PDE4APDE4BPDE4CPDE4DCYP1A1 | |
| SCHEMBL7054012 | 0.87 | IKBKB (0.39) | PDE4APDE4BPDE4CPDE4DAKR1C3 | |
| SCHEMBL7048142 | 0.86 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7056652 | 0.85 | SLC9A1 (0.37) | PDE4APDE4BPDE4CPDE4DHSD17B10 | |
| SCHEMBL7057558 | 0.85 | PDE4B (0.48) | PDE4APDE4BPDE4CPDE4DCYP1A1 | |
| SCHEMBL7055258 | 0.85 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DCYP1A1 | |
| SCHEMBL7050095 | 0.84 | MKNK2 (0.40) | PDE4BAKR1C3AKR1C2IKBKBLMNA | |
| O-Tolylamine SCHEMBL7366469 | 0.83 | IKBKB (0.38) | PDE4APDE4BPDE4CPDE4DAKR1C3 | |
| SCHEMBL7052315 | 0.83 | ALDH1A1 (0.48) | IKBKBLMNARECQLL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901482-B1 | BENZOFURAN CARBOXAMIDES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2003-05-02 | — | — | EP | disclosed |