Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 6/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.45 |
| ▸ | POLB | P06746 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.35 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.35 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.35 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7051176 | 0.85 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL7049222 | 0.84 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL7052699 | 0.83 | IKBKB (0.45) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL7056722 | 0.83 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL7054012 | 0.81 | IKBKB (0.39) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL7057558 | 0.81 | PDE4B (0.48) | PDE4APDE4BPDE4CPDE4DCYP1A1 | |
| SCHEMBL7402562 | 0.80 | CYP1A1 (0.39) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL7362735 | 0.80 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL7056652 | 0.80 | SLC9A1 (0.37) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL7053044 | 0.79 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901482-B1 | BENZOFURAN CARBOXAMIDES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2003-05-02 | — | — | EP | disclosed |