Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.33 |
| ▸ | MMP2 | P08253 | 2/20 | 0.33 |
| ▸ | MMP8 | P22894 | 2/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | PPIP5K2 | O43314 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL337595 | 0.71 | MMP1 (0.34) | MMP1MMP2MMP8MMP3DGAT1 | |
| SCHEMBL2236605 | 0.69 | DGAT1 (0.35) | MMP1MMP2MMP8MMP3DGAT1 | |
| SCHEMBL18262779 | 0.69 | DGAT1 (0.41) | DGAT1 | |
| SCHEMBL2238607 | 0.68 | FDPS (0.45) | MMP1MMP2MMP3PTPN1 | |
| SCHEMBL992 | 0.68 | DGAT1 (0.41) | MMP1MMP2MMP8MMP3DGAT1 | |
| SCHEMBL7048475 | 0.67 | MMP1 (0.31) | MMP1MMP2MMP8MMP3DGAT1 | |
| SCHEMBL2242180 | 0.67 | FDPS (0.43) | DGAT1 | |
| SCHEMBL9697626 | 0.66 | DGAT1 (0.39) | MMP1MMP2MMP8MMP3DGAT1 | |
| SCHEMBL1691823 | 0.65 | FDPS (0.45) | MMP1MMP2MMP3PTPN1 | |
| Hexane SCHEMBL27565209 | 0.65 | FDPS (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906015-A4 | LIVER RETENTION CLEARING AGENTS | NEORX CORP (US) | 2004-05-12 | — | — | EP | disclosed |
| EP-0906015-A1 | LIVER RETENTION CLEARING AGENTS | NEORX CORPORATION (US) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997046099-A1 | LIVER RETENTION CLEARING AGENTS | NEORX CORPORATION (US) | 1997-12-11 | — | — | WO | disclosed |