Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | DRD1 | P21728 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | DRD5 | P21918 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SI | P14410 | 1/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6483702 | 0.81 | HTR2C (0.59) | JAK2JAK1TYK2JAK3HPGD | |
| SCHEMBL6483706 | 0.81 | HTR2C (0.59) | JAK2JAK1TYK2JAK3HPGD | |
| Hydrochloric Acid SCHEMBL7044040 | 0.80 | HTR2C (0.58) | JAK2JAK1TYK2JAK3HPGD | |
| Hydrochloric Acid SCHEMBL8377589 | 0.80 | HTR2C (0.58) | JAK2JAK1TYK2JAK3HPGD | |
| SCHEMBL23755099 | 0.79 | SETDB1 (0.44) | JAK2JAK1TYK2JAK3ENPP2 | |
| SCHEMBL30791546 | 0.79 | SETDB1 (0.53) | JAK2JAK1TYK2JAK3ENPP2 | |
| SCHEMBL30305200 | 0.79 | ABCB1 (0.43) | JAK2JAK1TYK2JAK3ENPP2 | |
| SCHEMBL23775495 | 0.79 | ABCB1 (0.43) | JAK2JAK1TYK2JAK3ENPP2 | |
| SCHEMBL7050773 | 0.77 | ALDH1A1 (0.42) | JAK2JAK1TYK2JAK3HPGD | |
| SCHEMBL29196350 | 0.73 | HTR2A (0.47) | HTR2AIDH1ALDH1A1KCNH2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0773955-B1 | NEW THROMBIN INHIBITORS, THEIR PREPARATION AND USE | BASF AG (DE) | 2003-04-16 | — | — | EP | disclosed |
| EP-0773955-A1 | NEW THROMBIN INHIBITORS, THEIR PREPARATION AND USE | BASF AKTIENGESELLSCHAFT (DE) | 1997-05-21 | — | — | EP | disclosed |
| WO-1995035309-A1 | NEW THROMBIN INHIBITORS, THEIR PREPARATION AND USE | BASF AKTIENGESELLSCHAFT (DE) | 1995-12-28 | — | — | WO | disclosed |