Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 7/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7053533 | 0.81 | HTT (0.56) | KMT2ALMNAMEN1MAPTTSHR | |
| SCHEMBL7046729 | 0.78 | ALDH1A1 (0.43) | KMT2ALMNAMAPK1MEN1MAPT | |
| SCHEMBL7048623 | 0.77 | HTT (0.67) | KMT2ALMNAMAPK1MEN1MAPT | |
| SCHEMBL7062034 | 0.76 | KMT2A (0.53) | KMT2ALMNAMAPK1MEN1MAPT | |
| SCHEMBL5851166 | 0.76 | P2RY12 (0.61) | KMT2ALMNAMEN1MAPTNPSR1 | |
| SCHEMBL7046754 | 0.73 | ALDH1A1 (0.48) | KMT2ALMNAMAPK1MEN1MAPT | |
| SCHEMBL7051744 | 0.72 | HTT (0.53) | KMT2ALMNAMAPK1MEN1MAPT | |
| SCHEMBL7052962 | 0.72 | KMT2A (0.40) | KMT2ALMNAMAPK1MEN1MAPT | |
| SCHEMBL7055758 | 0.70 | TP53 (0.45) | KMT2AMEN1MAPTTSHRSMN1; SMN2 | |
| SCHEMBL5849182 | 0.69 | KMT2A (0.53) | KMT2ALMNAMAPK1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003022214-A2 | PIPERAZINE AND HOMOPIPERAZINE COMPOUNDS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2003-03-20 | — | — | WO | disclosed |