Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.43 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7050856 | 0.89 | MEN1 (0.51) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL9518234 | 0.77 | ALDH1A1 (0.50) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL7792214 | 0.76 | RXRA (0.39) | MAPTHTT | |
| SCHEMBL7988768 | 0.76 | MEN1 (0.68) | ALDH1A1GAAKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL13915098 | 0.76 | KDM4E (0.56) | ALDH1A1GAAKDM4ESMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL7056526 | 0.74 | ESR1 (0.68) | ALDH1A1MEN1KMT2AMAPTCYP2D6 | |
| SCHEMBL9623299 | 0.74 | PLAU (0.45) | CYP2D6CYP3A4 | |
| SCHEMBL19317250 | 0.72 | KMT2A (0.59) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL7792403 | 0.72 | TNFRSF1A (0.48) | ALDH1A1 | |
| SCHEMBL11528246 | 0.71 | CHRNA7 (0.47) | ALDH1A1KDM4EMEN1KMT2APSMB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0791590-B1 | Benzothiophenes, and formulations and methods using same | LILLY CO ELI (US) | 2003-05-02 | — | — | EP | disclosed |
| US-6432982-B1 | TREATING POST-MENOPAUSAL WOMEN HAVING OSTEOPOROSIS, CARDIOVASCULAR DISORDERS AND ESTROGEN-DEPENDENT CANCER; RESTENOSIS INHIBITION; ENDOMETRIOSIS | ELI LILLY AND COMPANY | 2002-08-13 | — | — | US | disclosed |
| WO-1997030985-A1 | BENZOTHIOPHENES, AND FORMULATIONS AND METHODS, USING SAME | ELI LILLY AND COMPANY (US) | 1997-08-28 | — | — | WO | disclosed |
| EP-0791590-A1 | Benzothiophenes, and formulations and methods using same | ELI LILLY AND COMPANY (US) | 1997-08-27 | — | — | EP | disclosed |