Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.50 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.50 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.50 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7048689 | 0.89 | ALDH1A1 (0.57) | MEN1KMT2AKDM4EPSMB1PSMB5 | |
| SCHEMBL9518234 | 0.87 | ALDH1A1 (0.50) | MEN1KMT2AKDM4EPSMB1PSMB5 | |
| SCHEMBL7988768 | 0.86 | MEN1 (0.68) | MEN1KMT2AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL13915098 | 0.83 | KDM4E (0.56) | MEN1KMT2AKDM4EPSMB1PSMB5 | |
| SCHEMBL11528246 | 0.81 | CHRNA7 (0.47) | MEN1KMT2AKDM4EPSMB1PSMB5 | |
| SCHEMBL9622975 | 0.79 | PLAU (0.49) | MEN1KMT2AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL11527115 | 0.79 | MEN1 (0.47) | MEN1KMT2AKDM4EHTTSMN1; SMN2 | |
| SCHEMBL14578269 | 0.77 | ALDH1A1 (0.55) | KDM4EHTTSMN1; SMN2HTR1AALDH1A1 | |
| SCHEMBL6996167 | 0.77 | ALDH1A1 (0.55) | MEN1KMT2AKDM4EHTTSMN1; SMN2 | |
| SCHEMBL2319002 | 0.77 | KMT2A (0.57) | MEN1KMT2AKDM4EHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0791590-B1 | Benzothiophenes, and formulations and methods using same | LILLY CO ELI (US) | 2003-05-02 | — | — | EP | disclosed |
| US-6432982-B1 | TREATING POST-MENOPAUSAL WOMEN HAVING OSTEOPOROSIS, CARDIOVASCULAR DISORDERS AND ESTROGEN-DEPENDENT CANCER; RESTENOSIS INHIBITION; ENDOMETRIOSIS | ELI LILLY AND COMPANY | 2002-08-13 | — | — | US | disclosed |
| EP-0791590-A1 | Benzothiophenes, and formulations and methods using same | ELI LILLY AND COMPANY (US) | 1997-08-27 | — | — | EP | disclosed |