Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.37 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.36 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.36 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5033481 | 0.98 | MAPT (0.39) | ALDH1A1MAPTSPHK2SPHK1NPC1 | |
| SCHEMBL5036213 | 0.97 | ALDH1A1 (0.40) | ALDH1A1TSHRHSD17B10MAPTNPC1 | |
| SCHEMBL5043032 | 0.91 | SPHK2 (0.46) | ALDH1A1MAPTSPHK2SPHK1NPC1 | |
| SCHEMBL5037959 | 0.90 | SPHK2 (0.49) | ALDH1A1MAPTSPHK2SPHK1NPC1 | |
| SCHEMBL7138529 | 0.89 | ENPP3 (0.39) | MAPTNPC1RAB9AENPP3ENPP1 | |
| SCHEMBL5037677 | 0.89 | MET (0.45) | TSHRMAPTNPC1RAB9AENPP3 | |
| SCHEMBL5033450 | 0.87 | MAPT (0.41) | MAPTNPC1RAB9AENPP3ENPP1 | |
| SCHEMBL5037847 | 0.85 | MET (0.42) | MAPTNPC1RAB9AENPP3ENPP1 | |
| SCHEMBL5043014 | 0.85 | ENPP3 (0.39) | MAPTNPC1RAB9AENPP3ENPP1 | |
| SCHEMBL5041011 | 0.85 | NPC1 (0.50) | ALDH1A1MAPTNPC1RAB9AENPP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432417-A2 | SUBSTITUTED BENZIMIDAZOLE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER | Aventis Pharma S.A. (FR) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003028721-A2 | SUBSTITUTED BENZIMIDAZOLE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER | AVENTIS PHARMA S.A. (FR) | 2003-04-10 | — | — | WO | disclosed |