Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGK1 | P00558 | 4/20 | 0.79 |
| ▸ | PGK2 | P07205 | 4/20 | 0.79 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.73 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.73 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.73 |
| ▸ | TSHR | P16473 | 2/20 | 0.73 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.73 |
| ▸ | THPO | P40225 | 1/20 | 0.73 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1120648 | 0.91 | ADORA3 (0.72) | PGK1PGK2ADORA3ADORA1ADORA2A | |
| SCHEMBL7771098 | 0.90 | PGK1 (0.64) | PGK1PGK2ADORA3ADORA1ADORA2A | |
| SCHEMBL5694952 | 0.90 | PGK1 (0.64) | PGK1PGK2ADORA3ADORA1ADORA2A | |
| SCHEMBL31201331 | 0.87 | ADORA1 (0.88) | PGK1PGK2ADORA3ADORA1ADORA2A | |
| SCHEMBL5414368 | 0.86 | ADORA2A (0.72) | ADORA3ADORA1ADORA2A | |
| SCHEMBL6328801 | 0.86 | PGK1 (0.71) | PGK1PGK2ADORA3ADORA1ADORA2A | |
| SCHEMBL6328795 | 0.86 | PGK1 (0.71) | PGK1PGK2ADORA3ADORA1ADORA2A | |
| SCHEMBL1120606 | 0.85 | CYP1A2 (0.71) | ADORA3ADORA1ADORA2ATSHRNFKB1 | |
| SCHEMBL1054862 | 0.84 | ADORA3 (1.00) | PGK1PGK2ADORA3ADORA1ADORA2A | |
| SCHEMBL1054866 | 0.84 | ADORA3 (1.00) | PGK1PGK2ADORA3ADORA1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1220863-B1 | PURINE DERIVATIVES | PFIZER LTD (GB) | 2003-04-23 | — | — | EP | disclosed |
| US-6350735-B1 | Purine derivatives | PFIZER INC | 2002-02-26 | — | — | US | disclosed |