Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | ACHE | P22303 | 2/20 | 0.54 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.52 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.52 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.52 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.52 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.52 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.52 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.52 |
| ▸ | CTSL | P07711 | 3/20 | 0.49 |
| ▸ | PGK1 | P00558 | 3/20 | 0.49 |
| ▸ | PGK2 | P07205 | 3/20 | 0.49 |
| ▸ | NT5E | P21589 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7049955 | 1.00 | ALDH1A1 (0.55) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL7049953 | 1.00 | ALDH1A1 (0.55) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL1120509 | 0.92 | ACHE (0.62) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL1120510 | 0.92 | ACHE (0.62) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL1120513 | 0.92 | ACHE (0.62) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL4804987 | 0.89 | LMNA (0.59) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL4805006 | 0.89 | LMNA (0.59) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL4804998 | 0.89 | LMNA (0.59) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL5406159 | 0.89 | ALDH1A1 (0.55) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL5406154 | 0.89 | ALDH1A1 (0.55) | ALDH1A1LMNATP53MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1220863-B1 | PURINE DERIVATIVES | PFIZER LTD (GB) | 2003-04-23 | — | — | EP | disclosed |
| US-6350735-B1 | Purine derivatives | PFIZER INC | 2002-02-26 | — | — | US | disclosed |