Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | P2RY12 | Q9H244 | 15/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7051621 | 0.88 | TP53 (0.47) | TP53MAPTTSHRHTTSMN1; SMN2 | |
| SCHEMBL7046759 | 0.88 | HTR6 (0.60) | TP53MAPTTSHRHTTSMN1; SMN2 | |
| SCHEMBL7050247 | 0.87 | P2RY12 (0.46) | TP53MAPTTSHRHTTSMN1; SMN2 | |
| SCHEMBL7055819 | 0.87 | TP53 (0.46) | TP53MAPTTSHRHTTSMN1; SMN2 | |
| SCHEMBL7047637 | 0.85 | TP53 (0.45) | TP53MAPTTSHRHTTSMN1; SMN2 | |
| SCHEMBL7055758 | 0.85 | TP53 (0.45) | TP53MAPTTSHRHTTSMN1; SMN2 | |
| SCHEMBL7048623 | 0.83 | HTT (0.67) | TP53MAPTTSHRHTTSMN1; SMN2 | |
| SCHEMBL7062011 | 0.77 | HTR6 (0.52) | HTR6P2RY12MEN1 | |
| SCHEMBL7047651 | 0.77 | HTT (0.45) | TP53MAPTTSHRHTTSMN1; SMN2 | |
| SCHEMBL5849483 | 0.77 | P2RY12 (0.70) | P2RY12MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003022214-A2 | PIPERAZINE AND HOMOPIPERAZINE COMPOUNDS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2003-03-20 | — | — | WO | disclosed |