Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN4A | P35499 | 2/20 | 0.43 |
| ▸ | BTK | Q06187 | 13/20 | 0.42 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.39 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27586539 | 0.84 | MEN1 (0.52) | SCN4ABTKHRH3ALDH1A1SMN1; SMN2 | |
| SCHEMBL28061472 | 0.83 | BTK (0.49) | SCN4ABTKNUDT14NUDT5HRH3 | |
| SCHEMBL28061471 | 0.83 | BTK (0.49) | SCN4ABTKNUDT14NUDT5HRH3 | |
| SCHEMBL27568293 | 0.83 | BTK (0.45) | SCN4ABTKNUDT14NUDT5HRH3 | |
| SCHEMBL23217070 | 0.81 | BTK (0.52) | SCN4ABTKNUDT14NUDT5HRH3 | |
| SCHEMBL6640044 | 0.81 | BTK (0.46) | SCN4ABTKNUDT14NUDT5HRH3 | |
| SCHEMBL28061492 | 0.78 | SMN1; SMN2 (0.49) | SCN4ABTKALDH1A1SMN1; SMN2 | |
| SCHEMBL28762061 | 0.78 | BTK (0.42) | SCN4ABTKHRH3MEN1KMT2A | |
| SCHEMBL28762063 | 0.78 | BTK (0.42) | SCN4ABTKHRH3MEN1KMT2A | |
| SCHEMBL18173591 | 0.78 | BTK (0.44) | SCN4ABTKALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101426792-A | Pyrazolopyrimidines as therapeutic agents | ABBOTT GMBH & CO KG (DE) | 2009-05-06 | — | — | CN | disclosed |
| WO-2004100868-A2 | METHOD OF TREATING TRANSPLANT REJECTION | ABBOTT LABORATORIES (US) | 2004-11-25 | — | — | WO | disclosed |
| CN-1520298-A | Pyrazolopyrimidines as therapeutic agents | �����ʩ���عɷݹ�˾ | 2004-08-11 | — | — | CN | disclosed |